research 3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes
A substance called TCQA could potentially darken hair by activating certain genes and increasing melanin.
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330-360 / 1000+ results research Desmoglein 4 Mutations Underlie Localized Autosomal Recessive Hypotrichosis in Humans, Mice, and Rats
Mutations in the DSG4 gene cause fragile, sparse hair in humans, mice, and rats.
research Systematic Review of Newer Agents for the Management of Alopecia Areata in Adults: Janus Kinase Inhibitors, Biologics and Phosphodiesterase-4 Inhibitors
New oral treatments for adult hair loss show promise, especially JAK inhibitors, with mild side effects.
research Determination of Protonation State in Molecular Salt of Minoxidil and 2,4-Dihydroxybenzoic Acid Through a Combined Experimental and Theoretical Study: Influence of Proton Transfer on Biological Activities
The MXD/24HA salt is more effective for hair growth than raw MXD.
research Neurotrophin-4 Modulates the Mechanotransducer Cav3.2 T-Type Calcium Current in Mice Down-Hair Neurons
Neurotrophin-4 increases calcium current in specific mouse neurons through the PI3K pathway.
research Testosterone Reduces Tight Junction Complexity and Down-Regulates Expression of Claudin-4 and Occludin in the Endometrium in Ovariectomized, Sex-Steroid Replacement Rats
Testosterone makes the connections in the uterus lining simpler and lowers certain protein levels, which might lead to infertility.
research Physiological Doses of Red Light Induce IL-4 Release in Cocultures Between Human Keratinocytes and Immune Cells
Red light at 627 nm can safely trigger IL-4 release in skin cells, potentially helping treat inflammatory skin conditions.
research Effects of Testosterone on Mean Arterial Pressure and Aquaporin Expressions in the Kidney of Orchidectomized Adult Male Sprague-Dawley Rats
Testosterone raises blood pressure and changes kidney protein levels.
research Selected Variants of the Melanocortin 4 Receptor Gene (MC4R) Do Not Confer Susceptibility to Female Pattern Hair Loss
MC4R gene variants not linked to female hair loss.
research Polyglandular Autoimmune Syndrome Type 4 with GAD Antibody and Dystonia
Dystonia may be part of PAS-4 and linked to immune issues.
research Effects of Hura Crepitans and Its Active Ingredient, Daphne Factor F3, on Dihydrotestosterone-Induced Neurotrophin-4 Activation and Hair Retardation
Hura crepitans and its compound daphne factor F3 may help treat hair loss by blocking a specific hair growth inhibitor.
research A Potential Role for IL-4 and IL-13 in an Alopecia Areata–Like Phenotype: A Clinical Perspective
IL-4 and IL-13 might play a role in a type of hair loss similar to alopecia areata.
research Activity of Steroid 4 and Derivatives 4a–4f as Inhibitors of the Enzyme 5α-Reductase Type 1
Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.
research 3D Spheroid Human Dermal Papilla Cell as an Effective Model for the Screening of Hair Growth Promoting Compounds: Examples of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid (TCQA)
3D cell cultures are better for testing hair growth treatments than 2D cultures.
research Studying Cytotoxic T-Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Polymorphism in a Sample of Iraqi Women with Polycystic Ovarian Syndrome
The CTLA-4 gene change studied does not affect Polycystic Ovarian Syndrome in the women tested.
research From Industry 4.0 to Lab 4.0
Industry 4.0 is transforming labs with new tools, making research more efficient and environmentally friendly.
research Viewpoint 4
Skin patterns form through molecular signals and genetic factors, affecting healing and dermatology.
research Adipose Tissue Remodeling via TSLP-Mediated IL-4/IL-13 Signaling: Implications for Atopic Dermatitis and Skin Barrier
TSLP affects atopic dermatitis by increasing sebum and reducing fat through IL-4/IL-13 signaling.
research The Evaluation of IL-4 Intron 3 VNTR and TNF-α (rs1799964) Gene Polymorphisms in Egyptian Patients with Alopecia Areata: A Case-Control Study
These specific gene polymorphisms are not linked to Alopecia Areata in Egyptians.
research Spatiotemporal Dynamics of Sensory Neuron and Merkel-Cell Remodeling During Epidermal Homeostasis
Sensory neuron remodeling and Merkel-cell changes in the skin happen independently.
research Investigation of Glypican-4 and -6 by Infrared Spectral Imaging During the Hair Growth Cycle
Infrared spectral imaging can effectively study protein distribution in hair follicles during hair growth.
research Establishment of 3D Spheroid Human Dermal Papilla Cells as an Effective Model for Hair Growth Screening Compounds Compared with the 2D System: An Example of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid
3D spheroid cultures of human hair follicle cells are better for hair growth research than 2D cultures, and they provide new insights into how hair growth treatments like minoxidil and TCQA work.
research The Clinical Differences in 2:4 Finger Ratios of Hirsute Women
Women with excessive hair growth tend to have shorter index and ring fingers compared to others.
research Autoimmune Polyglandular Syndrome Type 4 – Case Report
Patients with one autoimmune disease should be checked for other autoimmune disorders.
research A Peptide Derivative with Known Anti-Wrinkle Properties Identified as Potent Dipeptidylpeptidase-4 Inhibitor
A peptide known for reducing wrinkles also effectively inhibits an enzyme linked to skin inflammation and acne.
research Inhibition of Septin 4 (SEPT4; ARTS) for Wound Healing and Hair Follicle Regeneration: In Vitro and Mouse Studies
Blocking SEPT4 might help heal wounds and regrow hair faster.
research Is SFRP-4 an Early Potential Biomarker Related to Diabetes and Hypertension in Patients with Androgenic Alopecia?
SFRP-4 might be an early indicator of diabetes and hypertension in men with androgenic alopecia.
research 2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase
New compounds were made that block an enzyme linked to breast cancer better than existing treatments.
research Cloning of Wrinkle-Free, a Previously Uncharacterized Mouse Mutation, Reveals Crucial Roles for Fatty Acid Transport Protein 4 in Skin and Hair Development
Fatty acid transport protein 4 is essential for skin and hair development.
research Serum Levels of Retinol-Binding Protein 4 and Adiponectin in Women with Polycystic Ovary Syndrome: Associations with Visceral Fat but No Evidence for Fat Mass-Independent Effects on Pathogenesis in This Condition
Women with PCOS have similar levels of certain proteins compared to women without PCOS, and these proteins don't independently cause PCOS.