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The document concludes that diagnosing and treating Congenital Adrenal Hyperplasia is complex and requires a team approach due to its effects on the skin and other symptoms.

Using 17-hydroxyprogesterone levels to diagnose nonclassic congenital adrenal hyperplasia can result in many incorrect diagnoses.

Oral contraceptives lower testosterone levels in women, especially those with certain genetic traits, and may be linked to increased breast cancer risk.

Certain SHBG gene variants, like rs727428, are linked to higher testosterone levels in women with PCOS.

For women with moderate to severe unwanted hair growth or acne, birth control pills are the first choice, with other medications like cyproterone, spironolactone, flutamide, or finasteride as alternatives, and permanent hair removal should be done with electrolysis or laser.

Putting ketoconazole on the skin can help mice grow hair.

Male rats have androgen receptors in their liver, which are different from proteins that bind estrogen.

Blocking the FGF5 gene in sheep leads to more fine wool and active hair follicles due to changes in certain cell signaling pathways.

The medications 5α-reductase inhibitors and spironolactone are generally safe for breast cancer patients on endocrine therapies and do not significantly increase breast cancer risk.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

A woman had both Graham Little-Piccardi-Lassueur syndrome, causing hair loss, and complete androgen insensitivity syndrome, making her genetically male but physically female. This suggests androgens don't affect the hair loss condition.

Topical estrogen helps hair growth in menopausal women with no major side effects.

Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.

Finasteride reduces dihydrotestosterone, increases testosterone, and may treat hirsutism in women.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

Hormonal therapies help treat female hair loss, but results are slow and vary.

Acne is an important sign of androgen excess disorders in women.

Obese and non-obese women with PCOS have higher heart risk markers, especially if they are obese.

Women with PCOS, especially those overweight, have higher levels of IL-18 in their endometrium, which may affect fertility.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

Greek women with PCOS have a higher risk of metabolic syndrome and are more likely to be overweight compared to healthy controls.

17α-Estradiol solution safely improves hair density and thickness in female pattern hair loss.

The exact cause of growth hormone-responsive alopecia in dogs is unclear.

Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.

Lower lipin 1β in belly fat is linked to insulin resistance in people with polycystic ovary syndrome.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

A woman developed male traits from accidental contact with her husband's testosterone gel.

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

The document concludes that careful evaluation is needed to diagnose PCOS correctly due to similar symptoms in other conditions, and accurate testosterone level measurement is crucial.