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Normal levels of DHT can reduce belly fat and increase muscle, but too much can lead to hair loss, prostate issues, and possibly heart disease.

Genomic profiling for myeloid cancers can find important inherited mutations, but it's challenging when these mutations aren't related to the patient's symptoms.

Natural gene therapy shows promise for treating skin disorders like epidermolysis bullosa.

The document concludes that managing female hyperandrogenism requires a combination of identifying the cause, lifestyle changes, medication, and cosmetic treatments.

Dental pulp stem cells might not reliably become neurons.

Genetic defects in androgen production are linked to male developmental disorders and are improving treatment understanding.

New genes and pathways are important for testosterone production and male sexual development.

5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Gene mutations can cause problems in male genital development.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Oestrogens are key for bone growth during puberty in both boys and girls.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

The conclusion is that published guidelines are improving transgender medical care, but more research and education in transgender medicine are needed.

DHT, a testosterone byproduct, causes male pattern baldness.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Finasteride may cause male infertility, stopping it can help.

A male with aromatase deficiency improved bone health with estradiol treatment.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Steroidogenic isoenzymes may help improve treatments for common hair loss.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

The document says menstruation is important for women's health, discusses menstrual disorders, and suggests personalized treatment options.

Estrogens are key for bone growth spurts in both boys and girls and affect growth into adulthood.

5α-reductase inhibitors like finasteride may not be effective or safe for transgender individuals, and more research is needed.