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Researchers created long-lasting, diverse skin organoids from mouse hair follicle stem cells, useful for studying skin.

This review summarizes advancements in biomedical engineering for hair follicle regeneration, highlighting strategies like cell transplantation and tissue engineering to reconstruct hair follicles, and discusses both their technical limitations and potential future innovations in regenerative medicine.

This study found that lysine carboxymethyl cysteinate helps protect the epidermis from UVB-induced damage by activating autophagy and restoring cornification processes in a skin model.

Microfluidic models improve testing for aging, wound healing, and oral tissue, reducing animal testing.

This review discusses current and emerging therapies for androgenetic alopecia, emphasizing regenerative treatments and nanotechnology advancements, but it reports no new clinical results.

This study investigated a gelatin-based bioink for 3D bioprinting a simplified skin model, finding that a formulation with 15% gelatin and 150 mM calcium chloride supported a homogeneous distribution of viable cells over 14 days, showing promise for drug evaluation applications.

This study demonstrated that culturing high-passage dermal papilla cells with specific supplemented conditioned media may preserve their hair-inducing abilities, suggesting potential for reconstructing new hair follicles in vivo.

This study systematically reviews the development and applications of drug-loaded nanofiber scaffolds in wound healing, highlighting challenges such as maintaining drug activity and achieving controlled release, while summarizing preparation methods and describing advanced drug delivery schemes.

This study reviews 3D printing's role in neurology, highlighting its potential to enhance hair restoration and scalp therapy through personalized solutions, while acknowledging the challenges of regulatory issues and the need for further research on long-term effects.

This study found that non-balding dermal papilla cells emphasized extracellular matrix organization and reduced inflammation when cultured in 3D or with adipose-derived stem cells, unlike balding cells which maintained inflammatory pathways.

This study demonstrates that PAD1 and PAD3 are involved in hair follicle differentiation, while PAD1 and PAD2 may play a role in the physiology of sweat glands and arrector pili muscles.

In vitro skin models are improving but still need more innovation to fully replicate human skin.

This review highlights how organoid technology is transforming precision medicine by summarizing its development and applications in modeling diseases, testing drug efficacy, and tailoring patient-specific treatments, despite current challenges in standardization and ethical considerations.

This review highlights that synthetic biodegradable polymers like PVA, PCL, PLA, PLGA, PU, and PEO/PEG can address the limitations of natural polymers in wound healing, offering improved mechanical properties and slower degradation, thereby enhancing their application as wound dressings.

This review article summarizes recent advancements in biomimetic scaffolds, highlighting their promise in tissue engineering and personalized medicine, particularly for skin and musculoskeletal system regeneration, while emphasizing the need for more extensive research to ensure their safety for human use.

This review evaluates in vitro hair follicle models, techniques, and challenges without reporting new clinical results, emphasizing their future potential in hair transplantation.

This review discusses the characteristics, biomaterials, and tissue engineering methods for adipose-derived stem cells in a 3D environment, highlighting their potential in regenerative medicine without presenting new clinical results.

This review discusses the applications of biopolymeric composites in controlled drug release, tissue engineering, and wound healing, but reports no new experimental results, highlighting the need for further development and analysis.

This review discusses recent advancements in the study and application of epidermal stem cells for wound healing and tissue engineering, without presenting new experimental findings.

This study demonstrated that combining the Wnt/β-catenin activator CHIR99021 with 3D spheroid culture effectively enriched hair follicle formation in reconstituted human skin.

This review discusses the role of hair follicle stem cells as active signaling centers in skin homeostasis, highlighting recent advancements and reporting no new clinical results.

This study explored the use of "microfollicles," a human hair follicle organoid model, as an in vitro tool for testing hair-growth substances, finding up to 75% overlap in gene expression changes with human clinical biopsy responses to minoxidil, indicating its potential for pre-clinical substance testing.

This article discusses the potential of induced pluripotent stem cells (iPSCs) for generating skin components, particularly for genetic skin disorder modeling and gene-corrected regenerative therapies, but reports no new clinical results.

Dissolvable microneedles are a promising, painless method for effective skin treatments.

This study reviewed various methods and techniques aimed at overcoming limitations in culturing human hair follicles, specifically focusing on restoring the inductivity of hair follicle cells for successful hair regeneration.

This review study focused on various in vitro methods to evaluate skin permeation and retention of sunscreens, highlighting the importance of assessing sunscreen penetration due to widespread nanomaterial usage and advancements in cosmetic formulation.

This review discusses the biology and signaling mechanisms of dermal papilla cells in hair follicle growth and reports no new clinical results; the authors emphasize the importance of optimizing culture conditions for hair restoration.

In this study, researchers investigated the penetration and cellular responses to nanoplastics in human skin models with compromised barriers, finding that nanoplastics can penetrate the skin, accumulate in cells, and trigger inflammatory responses through specific signaling pathways.

The book provides updated methods for skin research and treatment.

This study found that hair treated with a supplemental hair care product showed significantly higher absorption, deeper penetration, and reduced dryness compared to untreated and water-treated hair, as measured with 3D Raman spectroscopy.