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At a workshop highlighted during the 2025 ESPCR meeting, researchers discussed the challenges and variability in culturing skin-related cells, identifying key factors such as media composition and species differences that affect experimental reproducibility, and emphasized the importance of transparent practices to advance pigment cell research.

In this study, fibroblasts from long-term skin biopsy cultures retained their ability to reprogram into induced pluripotent stem cells after 16 months, despite undergoing transcriptional changes and decreased proliferation rates over successive generations.

This study presented a refined surgical protocol for a fetal mouse model that improves pregnancy success, reduces fetal loss, and allows for consistent phenotypic outcomes, enhancing research in scarless skin regeneration.

This study observed that nevus melanocytes do not exhibit signs of senescence, suggesting that their growth arrest is due to cell interactions and not directly caused by BRAF activation.

This study suggests that the growth arrest of nevus melanocytes is not due to oncogene-induced senescence but rather to collective cell interactions, similar to those in normal tissue size regulation.

In laboratory and artificial skin model experiments, this study found that plant-derived PDRN from Korean ginseng effectively promoted skin cell regeneration and strengthened the skin barrier, suggesting a sustainable alternative to animal-derived PDRN.

This review outlines recent advances in stem cell and tissue engineering technologies in regenerative medicine and wildlife conservation, reporting no new clinical results.

This study found that salinity stress in Arabidopsis thaliana root hairs may inhibit hair extension through changes in the tip-focused Ca(2+) gradient, while cytosolic pH remains unaffected.

This study found that administering minoxidil and PGE₂ to pregnant mice with 22q11.2 deletion syndrome models corrected multiple developmental anomalies, including thymus growth and parathyroid positioning, by targeting prenatal mesenchymal differentiation.

This study observed that individuals with Down syndrome exhibit early immune dysregulation, including multi-organ autoimmunity and hypercytokinemia, and found that the JAK inhibitor tofacitinib showed a good safety profile and reduced skin pathology in a Phase II trial.

This study found that heart-inspired hollow hydrogel-based scaffolds enhanced regenerative capability in osteoporotic bone defects and increased cell number when using a mechanical-assisted post-bioprinting strategy.

This study analyzed the geometric and electronic properties of baicalin conformers, finding that BCLa2TT and BCLa1TT conformers exhibit high stability in aqueous solutions and are favorable for interactions with positively charged species.

In this paper, Chemistry42—a software integrating AI with computational and medicinal chemistry—demonstrated efficiency in designing novel molecular structures targeting DDR1 and CDK20, with properties validated in both in vitro and in vivo studies.

This study used numerical models to explore the cooling power required by different scalp cooling devices to prevent chemotherapy-induced hair loss, finding that coolant temperature significantly influences scalp tissue temperatures.

In this experimental study on rats, the researchers reported that administering minoxidil did not have significant electrophysiological or histopathological effects on penicillin-induced epilepsy, although future studies with larger sample sizes are recommended for more definitive conclusions.

This article presents a computer imaging algorithm that may automate and enhance the Severity of Alopecia Tool scoring for alopecia areata through texture analysis of pediatric images.

This study describes a protocol for generating hair follicle germ-like organoids from human skin cells, which may aid in alopecia drug discovery and understanding hair follicle regeneration.

Among families with pediatric brain disease, this study identified over 200 novel genetic causes, revealing potential treatment points using drug repurposing or nutritional supplementation.

This review discusses recent advances in microfabrication and microfluidic technologies for improving the production of organoids and spheroids, but it reports no new experimental results.

This study found that about 80% of known fullerene-binding proteins rank in the top 10% of scorers for C60 docking sites, confirming the accuracy of the predictive model used.

This review discusses the development of electrospun nanofibrous scaffolds for promoting angiogenesis in tissue engineering but notes that their clinical application beyond bone and skin repair is still limited.

This study found that certain keratin gene mutations associated with pachyonychia congenita are linked to altered enamel structure and increased risk of dental caries.

This study reports that dynamic interactions between stem cells and their niche, influenced by macro-environmental factors, regulate regenerative behavior in integument pattern formation.

This study found that ethanol extract of Tubtim Chumphae rice bran downregulates SRD5A gene expression, similarly to finasteride, suggesting potential use as an anti-hair loss product.

This study found that cultured mouse dermal papilla (mDP) cells can induce hair follicle neogenesis in de novo regenerated skin tissues grafted onto mice.

This study explored using a chitosan oligomer coating for topical delivery of dutasteride-loaded nanostructured lipid carriers, aiming to reduce systemic exposure and cytotoxicity.

This study found that SMAD2 overexpression in human hair follicle stem cells promoted differentiation and apoptosis while inhibiting proliferation, and Smurf2 upregulation limited mouse wound healing by suppressing the SMAD2/NANOG/DNMT1 axis.

This study utilized polarized light microscopy to examine hair shafts in ten children with rare genetic disorders, such as Netherton syndrome and ectodermal dysplasia, providing valuable diagnostic insights into hair thickness, composition, and structural irregularities associated with these conditions.

In this study, researchers used molecular docking to show that compounds from pomegranate peels, such as apigenin, luteolin, and taxifolin, effectively inhibit the enzyme 5α-reductase, suggesting potential anti-alopecic properties.

This research concluded that the novel hydrogel PlacMA, derived from human placenta and curable by visible light, shows promise for cell culture and tissue engineering applications due to its tunable properties.