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In this study, transplantation of hair follicle stem cells and nerve growth factor-modified stem cells significantly reduced amyloid deposition and tau hyperphosphorylation in an Alzheimer's disease rat model, suggesting potential as a treatment option.

This study found that preconditioning human hair follicle-derived stem cells with valproic acid enhanced their survival and migration in ischemic-like conditions by activating autophagy and inhibiting the AKT/mTOR pathway, suggesting this approach could improve stem cell therapies for ischemic stroke.

This study utilized a mouse model of traumatic brain injury to reveal that acute neurotrauma triggers widespread lipid metabolism reprogramming and storage lipid accumulation in microglial and monocyte populations, leading to lysosomal dysfunction, inhibited autophagy, and exacerbated inflammation through a pathological feedback loop.

In this study, the researchers reported that a newly developed PYGL inhibitor, HTPI, enhanced hair growth in an ex-vivo culture by reducing oxidative damage in hDPCs and inhibiting glycogen degradation in hORSCs, showing potential as a treatment for hair loss comparable to minoxidil.

This study explored the role of Twist2 in fetal wound healing in embryonic mice, observing that its expression was vital for scarless regeneration and normal hair follicle formation; Twist2 knockdown led to visible scars and defective follicle formation.

In this study, researchers found that the protein Twist2 plays a crucial role in scarless wound healing in early embryonic mouse skins, with its knockdown leading to visible scarring and defective hair follicle formation, suggesting potential therapeutic targets for reducing scars and promoting regeneration.

This study found that HDAC6 plays a crucial role in regulating primordial follicle activation, with its overexpression delaying activation and preserving fertility by reducing NGF levels.

This study found that inhibiting AP-1 transcription factors in mice causes squamous tumors to transform into sebaceous tumors and regulates tumor cell lineage.

This study found that inhibiting AP-1 activity in mice can induce lineage transdifferentiation between squamous and sebaceous tumors, suggesting AP-1's role in maintaining tumor cell identity.

This study used cashmere goats to reveal distinct intermediate states of dermal papilla cells, each with specific roles in hair growth, shedding, and regeneration.

This study suggests that epithelial-derived pop-up keratinocytes (ePUKs) may improve regenerative medicine applications due to their specific phenotype and increased expression of proteins involved in regulating cellular movement and wound healing.

In this study, researchers found that crude extracts from Avicennia marina and its component avicequinone C inhibit mechanisms contributing to androgenic alopecia in vitro, including 5α-reductase activity and DHT-AR interactions, potentially promoting hair growth and delaying the catagen phase in human dermal papilla cells.

This study suggests that hair follicle dermal stem/progenitor cells play a key role in both hair regeneration and skin wound healing, with potential implications for preventing hair follicle miniaturization linked to aging or alopecia.

In this in vitro study, minoxidil, diazoxide, and the novel compound NNC 55-0118 increased hair follicle growth, supporting deer follicles as a viable bioassay for ATP-sensitive potassium channel modulators.

This study observed that rat vibrissa hair follicles cultured in vitro showed morphological changes suggesting cyclical activity but remained blocked in the pro-anagen stage.

This review discusses the historical development and current challenges in in vitro hair follicle culture, highlighting a need for advanced models using cell lines and tissue engineering, and reports no new results.

This study reported the feasibility of detecting six cell-cycle-related nuclear markers in plucked human scalp and eyebrow hair, providing valuable insights for future intervention studies.

This exploratory study found that cannabidiol (CBD) at higher concentrations may inhibit hair growth by promoting the onset of catagen in human hair follicles, while lower concentrations showed potential anti-inflammatory effects without promoting catagen.

In this study, cryopreserved mouse whisker hair follicles were shown to maintain their hair growth potential and functional recovery, with DMSO being more effective than glycerol for cryopreservation.

This article provides industry updates on stem cell research and regenerative medicine from December 2019 and reports no new research findings.

AKR1B10 enzyme may cause keloid scars and could be a treatment target.

This study found that using a microwell array device to expand hair follicle stem cells in Matrigel significantly increased cell numbers and enhanced hair regeneration in mice.

This study found that ovine dermal papilla cells exhibit robust aggregation and alkaline phosphatase activity, regulated by Wnt/β-catenin signaling, providing insights for improving wool performance and hair regeneration therapies.

This review provides an overview of how advancing imaging technologies, such as tissue clearing and intravital microscopy, are enhancing our understanding of tumor architecture and interactions between cancer cells and the tumor microenvironment, aiding both fundamental cancer research and the development of therapies.

This study successfully optimized a culture strategy for dermal papilla cells and established an immortalized cell strain, iDP6, which is suitable for research and application.

This study found that HIF-1α suppression in dermal papilla cells of androgenetic alopecia patients reduces the expression of trichogenic genes, suggesting it as a potential target for hair loss treatment.

In this study, researchers developed gellan gum hydrogels functionalized with biomimetic peptides that create a supportive microenvironment for human dermal papilla cells, enhancing their hair-inductive capacity and ability to mimic hair morphogenesis-like events in vitro.

This study found that transplanted hair follicle-associated pluripotent stem cells in mice differentiated into keratinocytes and stimulated hair growth by producing mature hair shafts.

This study found that a new "bead-jet" printing system for mesenchymal stem cells in Matrigel beads improved skeletal muscle regeneration and skin healing in a high-density, sparse pattern.

This study found that bulge cells marked by CD200+ in human hair follicles show high colony-forming efficiency, suggesting successful enrichment of keratinocyte stem cells.