November 2022 in “Journal of Investigative Dermatology” This review analyzes granted patents for skin bioinks for 3D skin bioprinting from 2017 to 2022 and reports no new clinical results.
July 2022 in “Institutional Repositories DataBase (IRDB)” 3D spheroid cells effectively test hair growth compounds like Minoxidil.
November 2021 in “Research Square (Research Square)” This study found that human hair follicle dermal papilla cells grown in a 3D model influenced hair growth and immune pathways more effectively than those grown in a 2D culture.
October 2021 in “Postepy Dermatologii I Alergologii” This review discusses the future potential of 3D skin bioprinting for skin regeneration and reports no new experimental results.
This chapter reviews bioengineered human hair follicles and discusses the pros and cons of different 3-D bioprinting methods, but reports no new experimental findings.
March 2021 in “Research Square (Research Square)” This research observed that 3D electrospun micro/nanofibrous sponges, without using chemical crosslinking agents, supported enhanced cell growth, vascularization, and skin regeneration in diabetic rats compared to 2D fiber membranes, making them promising for 3D tissue regeneration.
July 2020 in “Research Square (Research Square)” This study found that a 3D co-culture of adipose-derived stem cells and endothelial colony forming cells restored stem cell properties and enhanced wound healing in a mouse model.
September 2019 in “Journal of Investigative Dermatology” This study found that co-culturing dermal papilla cells in a 3D structure with adipose-derived stem cells may enhance the expression of hair inductivity markers compared to 2D cultures.
September 2019 in “Journal of Investigative Dermatology” This study introduced a reproducible human model using 3D-SeboSkin technology to study hidradenitis suppurativa, allowing better maintenance of skin integrity and replication of biomarker expression patterns compared to traditional skin cultures, suggesting its value for further research.
September 2019 in “Journal of Investigative Dermatology” This study developed a 3D skin model with immune and endothelial cells, which may enhance understanding of skin biology and diseases due to its closer approximation to native skin.
January 2019 in “Cell & developmental biology” This study found that using 3D cultures and fetal tissue extracts significantly improved the outcomes of stem cell treatments for regenerative medicine, including hair follicle formation and chronic wound healing.
August 2018 in “Journal of Investigative Dermatology” This study found that combining optical clearing methods with light-sheet fluorescence microscopy allows detailed 3D visualization of normal and pathological human skin biopsies, revealing differences in epidermal thickness and volume.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study demonstrated that prevascularized human skin constructs containing engineered hair follicles can successfully induce human hair growth when grafted onto mice by promoting blood supply to the grafted skin.
April 2018 in “Journal of Investigative Dermatology” This study found that elevated STAT5 levels are linked to improved hair-inducing capabilities in human dermal papilla cells, and reducing STAT5 impairs hair follicle induction.
September 2016 in “Toxicology letters” The researchers reported that hydrogels made from methacrylated glycol chitosan and hyaluronic acid with chondroitin sulfate may be suitable for load bearing soft tissue repair, showing enhanced chondrocyte viability and metabolic activity.
August 2016 in “Journal of Investigative Dermatology” This study found that dihydrotestosterone alters the balance of Wnt pathway regulators in dermal papilla cells, hindering hair follicle stem cell differentiation and contributing to hair follicle miniaturization.
March 2014 in “Chinese Journal of Dermatology” This study found that dermal papilla cells from different scalp regions of AGA patients showed differential gene expression related to cell proliferation, apoptosis, and signaling pathways when exposed to DHT in a 3D culture.
October 2013 in “The New Scientist” New hair growth from skin cells may help cure baldness.
March 2023 in “International Journal of bioprinting” This study found that a bioprinted hydrogel scaffold with zinc and silicon ions significantly activated hair follicle stem cells and enhanced blood vessel formation, promoting hair growth in mouse wound models.
December 2022 in “Acta Biomaterialia” Corrections were made to a previous work on 3D printing a gel-alginate mix for creating hair follicles, but the main finding - that this method can help grow hair - remains the same.
13 citations
,
August 2007 in “Bioorganic & medicinal chemistry letters” This study developed a new competitive 5alpha-reductase inhibitor with an IC(50) of 0.84 microM using a novel chemical structure.
8 citations
,
February 2019 in “Scientific Reports” This article describes the immunofluorescence tomography method to achieve high-resolution 3-D reconstruction of epithelial tissues and reports no clinical results.
3 citations
,
August 2024 in “Biomimetics” In this study, researchers developed a silk fibroin-based hydrogel with added curcumin and pluronic F127, which displayed antibacterial properties against Methicillin-resistant Staphylococcus aureus and showed potential for skin tissue regeneration, without cytotoxicity.
1 citations
,
January 2024 CaBP1 and CaBP2 are necessary for proper hearing and neurotransmission in the ear's inner hair cells.
December 2024 in “Advanced Composites and Hybrid Materials” This study provides a comprehensive review of the use of electrospinning technology to create 3D porous structures for bone implants, emphasizing the synergy between biomedicine and materials science necessary for developing orthopedic materials.
CaBP1 and 2 are important for maintaining the activity of calcium channels necessary for hearing in inner ear cells.
CaBP1 and CaBP2 are necessary for proper hearing and neurotransmission in the ear's inner hair cells.
6 citations
,
January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin” In this study, TASP0382088 showed potent selective inhibition of the ALK5 receptor, significantly reducing Smad2 phosphorylation in mouse skin following topical application.
April 2026 in “Inflammopharmacology” This study found that Punica granatum ethanolic leaf extract may alleviate skin fibrosis in rats by modulating inflammation-related pathways and reducing dermal alterations.