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This review outlines the potential of using human pluripotent stem cells for hair follicle bioengineering, detailing current HF morphogenesis and cycling knowledge, various cell sources, and strategies using iPSCs, while discussing the challenges and prospects for therapeutic use in addressing hair loss.

This study observed that exosomes from adipose-derived stem cells promoted hair growth by enhancing dermal papilla cell proliferation and activating signaling pathways, suggesting potential for treating immune-mediated alopecia.

This study found that mitochondrial dysfunction and higher oxidative stress in balding dermal papilla cells may contribute to androgenetic alopecia, with antioxidants potentially improving metabolite uptake.

This study found that all-trans retinoic acid (ATRA) inhibits proliferation and promotes apoptosis in secondary hair follicle-derived dermal papilla cells from cashmere goats, likely via the TGF-β2/Smad2/3 signaling pathway.

In this perspective, recent advances in regenerative medicine, including bioartificial substitutes and engineered in vitro platforms, are reviewed for their potential to restore human hair follicles, highlighting new technologies like 3D printing, hair-on-a-chip models, and stem cell-derived organoids.

This study reviews advancements in hair follicle regeneration, discussing the benefits and limitations of methods such as organ germ assembling, stem cell induction, and bioprinting, while highlighting the challenges of replicating embryonic signals and finding suitable cell sources for clinical applications.

This review examines how skin organoids, derived from stem cells, are constructed to simulate skin functions and are pivotal in wound healing and regeneration, highlighting their promising roles in both research and therapeutic applications.

This review highlights that skin organoids, advanced three-dimensional models mimicking human skin, are emerging as effective alternatives to traditional culture models and human skin, overcoming limitations of two-dimensional systems and ethical concerns, and are being increasingly used in areas like developmental biology and disease modeling.

The researchers concluded that baicalin may promote hair growth and follicle proliferation by activating the AKT pathway, suggesting its potential as a treatment for alopecia.

This study found that essential oils boost hair growth activity in dermal papilla cells by scavenging reactive oxygen species and upregulating growth factor biomarkers.

This study found that knocking down SFRP2 in an AGA model improved hair regeneration and reduced cellular dysfunction, suggesting that targeting the SFRP2-FSTL1 axis could be a promising therapeutic strategy for androgenetic alopecia.

This review examines current and potential tissue engineering strategies for hair follicle regeneration in androgenetic alopecia but does not provide new clinical results, highlighting the need for further research and development.

This study found that stimulating dermal papilla cells with specific adipo-osteogenic factors and growth factors helped maintain their viability and restored their hair-forming activity in vitro.

The researchers reported that adenosine increases FGF-7 expression in dermal papilla cells, which may stimulate hair growth via the A2b adenosine receptor and cAMP pathway.

This study found that dermal papilla cells from beard and axillary hair follicles can produce androgen-dependent factors that stimulate proliferation in adjacent follicular epithelial cells under testosterone influence.

This study found that 5% activated platelet-rich plasma significantly improved cell proliferation and hair-inductive ability of dermal papilla cells in vitro, and promoted hair follicle formation in mice.

This study found that preconditioning adipose-derived stem cells with HB-EGF enhanced their ability to promote hair growth in vivo by increasing their motility, paracrine effects, and survival.

This study found that vanillic acid from wheat bran promoted dermal papilla cell proliferation, potentially stimulating hair growth by activating the PI3K/Akt and Wnt/β-catenin pathways.

This study found that the mitotic arrest deficient protein MAD2B negatively affects TCF4-induced growth and proliferation of dermal papilla cells, which are vital for hair follicle development.

This study found that elevated expression of the protein Zyxin in hair follicles is associated with androgenetic alopecia and suggests it may be targeted for therapy.

This study found that Camellia seed cake extract may counteract DHT-induced effects in cultured dermal papilla cells, suggesting potential to prevent or alleviate androgenetic alopecia.

This study identified that copper depletion in dermal papilla cells reduced hair growth by boosting ROS levels, but ROS scavengers like NAC and ascorbic acid partially alleviated this effect.

In this study, miR-181a was found to inhibit the proliferation and induction abilities of ovine dermal papilla cells by targeting the GNAI2 gene and affecting the Wnt/β-Catenin signaling pathway, highlighting its role in the regulation of hair follicle growth and development.

This study observed that SOX18 promotes the proliferation of dermal papilla cells in Hu sheep by activating the Wnt/β-Catenin signaling pathway, suggesting its key role in wool growth.

In this study, researchers found that overexpression of CRABP2 enhanced the proliferation of dermal papilla cells in Hu sheep through activation of the Wnt/β-catenin pathway, even when the pathway was inhibited.

This study found that low-passage exosomes from dermal papilla cells enhance hair follicle stem cell proliferation and that miR-218-5p may serve as a potential biomarker and therapeutic target for hair growth.

This study found that kaempferol may stimulate hair growth in androgenetic alopecia by enhancing dermal papilla cell function and reducing dihydrotestosterone-induced damage, showing comparable efficacy to finasteride in a mouse model.

This study found that PRP-Exos may stimulate hair follicle growth and enhance regeneration in cases of AGA by activating the Wnt/β-Catenin signaling pathway, showing potential both in vitro and in vivo.

This review discusses the role of dermal papilla cells in hair follicle formation and their potential use in cell therapy for hair loss, but reports no new research findings.

This laboratory study found that dendrobium officinale polysaccharide (DOP) stimulated hair follicle and hair growth in mice by activating the WNT signaling pathway.