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Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations, May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

research Stem Cell Dynamics in the Hair Follicle Niche

135 citations, December 2013 in “Seminars in Cell & Developmental Biology”

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

research The Disintegrin/Metalloproteinase Adam10 Is Essential for Epidermal Integrity and Notch-Mediated Signaling

134 citations, January 2011 in “Development”

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

research Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection

133 citations, May 2016 in “Cell Host & Microbe”

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

research Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging

132 citations, January 2017 in “International Journal of Molecular Sciences”

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

research The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization

131 citations, July 2009 in “Experimental Dermatology”

The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.

research Macrophages Regulate Schwann Cell Maturation After Nerve Injury

130 citations, September 2018 in “Cell Reports”

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis

research An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis

130 citations, February 2018 in “Journal of Investigative Dermatology”

Tofacitinib may help treat severe hair loss, but more research is needed.

In Vitro and In Vivo Evaluation of Biologically Synthesized Silver Nanoparticles for Topical Applications: Effect of Surface Coating and Loading into Hydrogels

research In Vitro and In Vivo Evaluation of Biologically Synthesized Silver Nanoparticles for Topical Applications: Effect of Surface Coating and Loading into Hydrogels

130 citations, January 2017 in “International journal of nanomedicine”

Silver nanoparticles coated with substances like PEG showed strong antibacterial effects and improved wound healing when used in hydrogels.

research Stem Cell Heterogeneity and Plasticity in Epithelia

129 citations, May 2015 in “Cell Stem Cell”

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

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