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The medication combination did not affect glucose tolerance but increased some cholesterol levels due to its estrogen component.

Finasteride may increase suicide risk; more research needed.

The study created a new method to test drugs that affect hormone processing in skin.

Taking Saw palmetto and Pygeum africana can change the levels of certain steroids in urine, which could cause confusion in doping tests.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Female pattern hair loss affects crown, increases with age, and has limited treatments.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

Finasteride may cause lasting sexual, mental, and physical symptoms; use with caution.

Male pattern baldness may be caused by factors like poor blood circulation, scalp tension, stress, and hormonal imbalances, but the exact causes are still unclear.

Finasteride treats hair loss but may cause low libido, erectile issues, and depression.

Cyproterone acetate is used to treat conditions like prostate cancer, early puberty, excessive sexual drive, and female androgenization by affecting androgen functions and suppressing certain hormones.

Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.

Lipid nanoparticles can help deliver drugs through hair follicles but struggle to penetrate deeper skin layers.

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

Finasteride's sexual side effects not caused by androgen deficiency or SRD5A inhibition.

The enzyme that changes testosterone to a stronger form is mostly found in the part of the hair follicle called the dermal papilla.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Rat skin takes up and processes testosterone differently than other organs, with testosterone being more important for the skin than its metabolite 5α-DHT.

The conclusion is that tritium-labeled testosterone metabolites can be made and are better converted into dihydrotestosterone in skin cells than in prostate tissue.

Sebocytes play a key role in controlling androgen levels in human skin.

Too much androgen can cause hair loss; finasteride may help.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

New genes and pathways are important for testosterone production and male sexual development.

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

Finasteride reduces alcohol withdrawal severity in male mice but increases it in female mice.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

Finasteride reduces hair growth and is safe for women with excessive hair.