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Nitrendipine and nifedipine effectively block muscle contractions, while papaverine relaxes them and minoxidil needs high amounts to work.

Skin symptoms are important for diagnosing and managing juvenile-onset systemic lupus erythematosus and usually get better with treatment.

People with polycystic ovary syndrome may have a higher risk of heart problems due to abnormal nervous system control of their heart and blood pressure.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

PRP shows promise for hair loss treatment, with three initial monthly injections and maintenance every 3-6 months.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Botulinum toxin has potential for treating various skin conditions and improving wound healing.

Targeted cancer therapies have a significant but lower risk of causing hair loss compared to chemotherapy.

5-α-reductase inhibitors reduce prostate cancer risk but may cause sexual dysfunction and don't affect high-grade tumor or death rates.

Gefitinib can cause skin problems, diarrhea, and nausea, but rarely causes severe lung disease or hair loss.

Finasteride and minoxidil mix works better for hair growth than minoxidil alone, with similar safety.

Hormonal therapies are safe and effective for treating adult women's acne.

All three shampoos reduced dandruff and hair loss, but ketoconazole and piroctone olamine also made hair thicker.

Germ-free rats need biotin for growth and have different vitamin metabolism compared to regular rats.

Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.

The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.

Apremilast was not effective in treating moderate-to-severe alopecia areata.

The conclusion is that oral contraceptives and antiandrogens can treat hirsutism and acne in women with cutaneous hyperandrogenism, but more research is needed for effective treatments, especially for hair loss.

Nonablative radiofrequency treatments, especially microneedle and fractional types, can improve acne scars by 25%–75% after 3-4 sessions, with full results in 3 months and some side effects.

Mutations in the KRT85 gene cause hair and nail problems.

The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.

Skin aging is largely due to differences in stiffness and elasticity between skin layers, leading to wrinkles.

Psoriasis can cause temporary or permanent hair loss.

MicroRNAs play a crucial role in skin and hair health, affecting everything from growth to aging, and could potentially be used in treating skin diseases.

Smoking harms skin health, causing slower wound healing, more wrinkles, and worsening some skin conditions, but may protect against certain others.

Taking L-cystine and vitamin B6 can prevent hair loss caused by smoke in mice.

New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.

New treatment combining PRP and SVF increases hair density in 6-12 weeks for androgenetic alopecia patients.

Some plants used in traditional medicine may help treat cancer because they contain proteins that can inactivate ribosomes.

Male skin gets drier and more alkaline as it ages, which may need different skincare than women's skin.