August 2023 in “Scientific reports” In this study, researchers differentiated human induced pluripotent stem cells into dermal papilla-like cells and observed gene expression dynamics during five stages of dermal differentiation, demonstrating the potential of these cells to interact with epidermal cells in functional assays.
August 2023 in “Cell Proliferation” This study observed that incorporating human follicle dermal papilla cells into fibrin microgels increased cell viability and the formation of hair follicle structures in in vitro skin cultures compared to traditional dermal papilla spheroids, suggesting a promising approach for hair follicle regeneration therapies.
551 citations
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November 2013 in “Nature” This study found that differentiated airway epithelial cells can revert into functional stem cells in vivo, suggesting a more general role for this dedifferentiation process in tissue regeneration in higher vertebrates.
9 citations
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October 2024 in “Burns & Trauma” This study demonstrates that using transwell culture significantly influences hair follicle formation in skin models, potentially improving dermatology and skin research methodologies.
3 citations
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January 2019 in “Advances in stem cells and their niches” This review discusses the role of dermal papilla cells in hair follicle morphogenesis and regeneration and reports no new results; the authors emphasize the importance of these cells in hair growth and pigmentation regulation.
169 citations
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June 2010 in “Molecular & cellular proteomics” This study suggests that ethylene and lignoceric acid (C24:0) may promote cotton fiber and Arabidopsis root hair growth by activating the pectin biosynthesis network.
54 citations
,
January 2021 in “Biophysics Reports” This review highlights the current progress and application pros and cons of various cell-based screening platforms in drug discovery, discussing challenges and potential improvements for these innovative methods.
14 citations
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May 2019 in “Experimental Dermatology” In this study, adipose tissue secretome was shown to enhance oxidative stress resistance and promote cell proliferation in vitiligo cells, suggesting a potential natural treatment approach.
9 citations
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September 2018 in “Journal of Photochemistry and Photobiology B-biology” This study demonstrated that combining l-cystine and thiamin in a formulation may protect against UV-induced damage in growth-limited human epidermal keratinocytes in vitro.
4 citations
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October 2017 in “Advances in tissue engineering & regenerative medicine” In this study, a bioengineered construct using a biodegradable polycaprolactone mat cocultured with human keratinocyte and rabbit dermal fibroblast cells demonstrated potential as a tissue-engineered skin substitute, showing good cell adhesion and growth.
3 citations
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August 2018 in “Stem cells international” This study found that cultured hair follicle dermal cells support maintenance and potentially aid in the clinical application of pluripotent and haematopoietic stem cells.
1 citations
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April 2025 in “Scientific Reports” This study developed a culture method to expand and differentiate primary mammary basal cells, identifying key transcription factors like EGR1 and ELF3 that influence Claudin expression and actin organization, offering insights into epithelial cell biology and potential applications in related research fields.
208 citations
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January 2013 in “Lab on a Chip” The researchers described a chip-based bioreactor platform for dynamic perfusion, which may enhance in vitro skin models by introducing mechanical shear stress and extending culture periods.
This study demonstrates that a novel autologous hair follicle-derived epithelial sheet can effectively repigment skin in patients with stable vitiligo, offering a potential new treatment option.
5 citations
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February 2023 in “Frontiers in Veterinary Science” This study found that ovine dermal papilla cells exhibit robust aggregation and alkaline phosphatase activity, regulated by Wnt/β-catenin signaling, providing insights for improving wool performance and hair regeneration therapies.
April 2017 in “Journal of Investigative Dermatology” This study observed that a 3D culture model of hair follicle cells showed an anagen-like phase between days 3 to 6 and transitioned to a catagen-like phase by day 7, highlighting cell differentiation and structural development over time.
1 citations
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October 2025 in “Frontiers in Bioengineering and Biotechnology” This study developed a multifunctional bilayer dressing containing nanosilver and basic fibroblast growth factor, which improved wound healing by preventing bacterial penetration, promoting angiogenesis and hemostasis, and accelerating cell proliferation and migration, outperforming a control group by increasing healing rates by 47% in vivo.
1 citations
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July 2025 in “Journal of Human Immunity” This study found that administering minoxidil and PGE2 to pregnant mice with 22q11.2 deletion syndrome models corrected multiple developmental anomalies, including thymus growth and parathyroid positioning, by targeting prenatal mesenchymal differentiation.
March 2022 in “Molecules” This study found that adenosine promotes hair growth by stimulating the Wnt/β-catenin pathway in cultured human dermal papilla cells through activation of the adenosine receptor.
43 citations
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August 2008 in “Regenerative Medicine” In this study, murine follicular cell aggregates developed into hair-like structures in culture, which upon implantation into mice skin matured into complete hair follicles, suggesting potential for treating hair loss.
This study suggests that skin tumor cells in tuberous sclerosis complex may promote hamartoma morphogenesis by expressing and releasing higher levels of cathepsin B.
13 citations
,
September 2017 in “Cytometry Part A” This study explored the dermal stem cell niche of equine hair follicles, revealing typical fibroblast morphology and confirming the expression of standard stem cell markers comparable to other species.
561 citations
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April 2003 in “Journal of Investigative Dermatology” CD34 is a marker for isolating stem-like cells in mouse hair follicles.
3 citations
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February 2021 in “Experimental dermatology” This study observed that using 3D dermal papilla microtissues enhances hair follicle regeneration and gene expression compared to 2D cultures, indicating their potential for hair growth drug screening.
18 citations
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June 2001 in “Journal of Investigative Dermatology” This study found that transfecting keratinocytes with the 1α-OHase gene enhances local production of 1α,25-dihydroxyvitamin D3, suggesting a potential new therapy for skin conditions like psoriasis without causing hypercalcemia or resistance.
39 citations
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December 2013 in “Phytotherapy Research” This study found that hydroxysafflor yellow A-rich Carthamus tinctorius extract promoted hair growth and gene expression linked to hair proliferation in both cell cultures and mouse models.
November 2023 in “Frontiers in veterinary science” In this study, researchers used yaks as a natural model to investigate hair growth mechanisms, overcoming previous limitations by establishing in vitro models of hair follicle-associated cells and optimizing methods for cell culture and differentiation.
22 citations
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November 2013 in “Clinical and experimental dermatology (Print)” This study suggests that Ecklonia cava, particularly its component dioxinodehydroeckol, may promote hair growth by enhancing dermal papilla and outer root sheath cell activity in culture and mice models.
12 citations
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April 2022 in “Journal of Bioscience and Bioengineering” This study found that activating the PI3K/Akt signaling pathway in dermal papilla cells enhances their hair-inducing capabilities, suggesting potential strategies for hair regenerative medicine.
88 citations
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August 2019 in “Nature communications” In this study, researchers identified a specific T cell receptor associated with carbamazepine-induced severe cutaneous adverse reactions, demonstrating its potential for therapeutic development in patients with the HLA-B*15:02 genotype.