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Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.

A substance called Compound 2g can strongly block STS (a hormone-related enzyme) without affecting estrogen levels, making it potentially good for treating breast cancer.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Researchers developed a method to measure drugs in hair follicles and found that both water-loving and fat-loving drugs can be detected after being applied to the skin.

Hair follicles are important for drug delivery through the skin, but better methods are needed to understand and improve this process.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

The new drug delivery system releases the drug better in sebum and targets follicles more effectively than the conventional cream.

New treatments for enlarged prostate are being developed, some of which may be more effective than current medications.

New treatments targeting androgen receptors show promise for drug-resistant prostate cancer.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Some chemicals absorbed through the skin can cause serious health problems.

Early treatment of acne is crucial to prevent scarring and psychological effects.

Bobby Limmer was crucial in developing a hair transplant method that uses natural hair groupings for a more realistic look.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

Scalp biopsies are essential for accurately diagnosing alopecia areata.

Temporary hair loss can occur after 5-fluorouracil treatment for keloids.

Botulinum A toxin injections reduced pain and promoted hair regrowth in a woman with a rare form of alopecia areata.

Certain drugs that block specific enzymes can help treat prostate diseases.

14,15-EET may help reduce poststroke pain by affecting certain brain proteins.

Adapalene 0.1% effectively reduces acne by decreasing comedones and altering skin properties.

A systematic approach is crucial for managing hair loss in women.

The document reviews key historical figures and discoveries in dermatology.

Hair transplant improved self-perception in hair loss patients, but some still remained overly focused on their hair appearance.

Finasteride for hair loss is safe and does not increase the risk of high-grade prostate cancer.

Orlistat might block the body's ability to absorb thyroid medication.

The paper suggests improving diagnosis and treatment of telogen effluvium but does not recommend a new classification system.

A man's bald spot grew hair after starting cancer treatment with gefitinib.

Hair loss that spreads out can often fix itself or be treated by finding and handling the cause.