50 citations,
November 2010 in “Plastic and Reconstructive Surgery” Botox increased hair count in men with baldness and might work by improving scalp blood flow.
49 citations,
March 2017 in “Journal of the American Academy of Dermatology” Tofacitinib caused significant hair regrowth in adolescents with alopecia universalis who didn't respond to other treatments.
48 citations,
February 2011 in “Circulation” Cardiovascular disease deaths decreased but still caused one-third of U.S. deaths in 2007, with high rates of hypertension, smoking, obesity, and diabetes.
48 citations,
October 2010 in “Archives of Dermatological Research” The study evaluated the effectiveness of Juvéderm hyaluronic acid fillers for wrinkle correction in nasolabial folds (NLFs) over 1 year following repeat treatments. A total of 80 subjects participated, with a median injection volume of 1.5–1.6 mL for initial treatment and 0.5–0.6 mL for repeat treatment. Results showed significant improvement in NLF severity scores, with scores decreasing from 2.5–2.7 (moderate to severe) at baseline to 0.7–0.9 (mild) at 4 weeks post-repeat treatment. At 48 weeks post-repeat treatment, 78–90% of subjects were responders, sustaining wrinkle correction for 18–21 months with 60% less filler needed for repeat treatments, suggesting that retreatment at 6–9 months is beneficial.
47 citations,
July 2014 in “Journal of Dermatological Treatment” Most treatments for lichen planopilaris were found to be generally unsatisfactory.
46 citations,
May 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” Disrupting Acvr1b in mice causes severe hair loss and thicker skin.
44 citations,
April 2019 in “Journal of the American Academy of Dermatology” Cyclosporine showed some improvement in alopecia areata but results were not statistically significant.
43 citations,
February 2008 in “Journal of cutaneous pathology” Melanocyte precursors in human fetal skin follow a specific migration pattern and some remain in the skin's deeper layers.
42 citations,
January 2008 in “Dermatology” Dermoscopy effectively distinguishes between acute total hair loss and other types of female hair loss.
41 citations,
October 2012 in “Australian and New Zealand Journal of Psychiatry” Negative expectations can cause adverse effects in patients even without active treatment, and managing this nocebo effect involves better communication and patient-clinician relationships.
40 citations,
February 2005 in “Fertility and Sterility” Some women with PCOS have CYP21 mutations and IRS1 variants, but these genetic factors are not major contributors to PCOS.
39 citations,
March 2022 in “Nature Protocols” Researchers have developed a protocol to generate hair-bearing skin tissue from human pluripotent stem cells in a 3D in vitro culture system. Over 2 weeks, these stem cells differentiate into surface ectoderm and cranial neural crest cells, forming the epidermis and dermis. After 60 days, hair follicles appear, and by 130 days, the organoids exhibit full complexity, including stratified skin layers, pigmented hair follicles, sebaceous glands, Merkel cells, and sensory neurons, mimicking fetal skin at 18 weeks of gestation. These organoids can be cultured for up to 150 days, offering a model for studying skin biology, disease, and potential skin tissue regeneration.
38 citations,
May 2017 in “Journal of The American Academy of Dermatology” Many skin patients have mental health issues, but few dermatologists are well-versed in treating these conditions.
38 citations,
October 2014 in “British journal of dermatology/British journal of dermatology, Supplement” Bimatoprost solution is effective and safe for long-term use in treating eyelash thinning.
37 citations,
December 2001 in “Journal of the American Academy of Dermatology” Thalidomide significantly improved hair regrowth in a woman with lichen planopilaris.
37 citations,
June 2000 in “Experimental dermatology” The Lanceolate hair-J mutation in mice mimics human hair disorders like Netherton's syndrome.
35 citations,
January 2009 in “Indian Journal of Dermatology, Venereology and Leprology” Older adults commonly experience wrinkles, itchy skin, psoriasis, fungal infections, skin growths, grey hair, hair loss, and nail ridging, but no skin cancer was found in this group.
35 citations,
August 1978 in “Australian Veterinary Journal” Feeding steers only Leucaena leucocephala causes severe health issues and poor weight gain.
34 citations,
March 2015 in “Clinical and Experimental Dermatology” People with pemphigus are more likely to have conditions like hypothyroidism, inflammatory bowel disease, and diabetes.
34 citations,
October 2011 in “International journal of pharmaceutics” Ion-paired risedronate significantly increases skin penetration without irritation compared to risedronate alone.
34 citations,
June 2007 in “The Journal of Dermatology” Most Korean systemic lupus erythematosus patients experienced hair loss, often as non-scarring diffuse hair loss, with non-scarring patch alopecia also common.
32 citations,
March 2017 in “Human Reproduction” Women with polycystic ovary syndrome tend to have a longer anogenital distance.
30 citations,
September 2016 in “BMJ” Taking 5-α reductase inhibitors for prostate enlargement or hair loss does not significantly raise the risk of erectile dysfunction.
30 citations,
December 1999 in “International Journal of Dermatology” Oral ivermectin effectively cured scabies with minimal side effects, and finasteride promoted hair growth in men with hair loss.
30 citations,
December 1972 in “Archives of dermatology” The steroid solution can regrow hair but often causes skin issues and doesn't work long-term.
29 citations,
June 2014 in “Drug delivery” The new formulation improved the skin absorption of the drug Thiocolchicoside.
29 citations,
November 2011 in “Cell stress & chaperones” Quercetin effectively treated and prevented hair loss in mice.
28 citations,
August 2013 in “Facial Plastic Surgery Clinics of North America” Body and beard hair can be used for hair restoration in severely bald patients, but the technique is complex and costly.
28 citations,
July 2013 in “Journal of Craniofacial Surgery” Hair follicle transplantation can hide scars but often needs more than one surgery for better results.
26 citations,
November 2016 in “European Journal of Clinical Pharmacology” Valproic acid helps delay hair loss and increases survival time for high-grade glioma patients undergoing radiation therapy.