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The document concludes that there are still unknowns about the effectiveness, risks, and detection of performance-enhancing drugs, and doping remains a challenge.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.

Pfizer found that pantolactam-based compounds can reduce sebum (skin oil) production when applied topically.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Hair and wool have complex microscopic structures with microfibrils and varying cystine content.

Adrenal disorders can cause lasting brain and behavior issues in children.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.

Androgen therapy can help with symptoms like low libido in women, but more research is needed to understand its long-term safety and effects on health.

DHEA acts like a male hormone on rat skin glands and doesn't turn into female hormones there.

DHEA stimulates skin oil glands and could help postmenopausal women, with potential for acne and excessive hair growth treatments.

Certain adrenal hormones can strongly stimulate oil gland growth in hamster skin, similar to male hormones.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Nannochloropsis salina fermented oil may help treat hair loss by promoting hair growth and reducing oxidative stress.

Current treatments for Alopecia Areata have mixed success, and there's a need for better, more accessible options and support for affected individuals.

Histone modification is key in treating chronic inflammatory skin diseases.

Angora goat hair grows faster and produces more protein than cashmere goat hair, and certain hormones and nutrients positively affect hair growth and protein synthesis.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Semecarpus anacardium leaf extract fights breast cancer and extends survival in mice.

Testosterone replacement may help post-menopausal women with androgen insufficiency, but more research is needed on its benefits and risks.

Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.

Possible new treatments for common hair loss include drugs, stem cells, and improved transplants.

Fetal skin has unique immune cells different from adult skin.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

CBD may improve skin and hair health, but its effective use and safety need more research.