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Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Finasteride shows promise for female hair loss, but more research needed.

Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.

Steroidogenic isoenzymes may help improve treatments for common hair loss.

A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.

Consider benefits and risks of new alopecia treatments for safety.

Normal levels of DHT can reduce belly fat and increase muscle, but too much can lead to hair loss, prostate issues, and possibly heart disease.

Male hormones indirectly affect skin cell development by increasing growth factor levels from skin fibroblasts.

Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.

Women with AGA have more androstenedione and dihydrotestosterone, less copper and zinc; copper imbalance affects AGA; treatment improves hormones and minerals.

Understanding hair biology is key to developing better treatments for hair and scalp issues.

New hormonal treatments for enlarged prostate show promise for safer, effective non-surgical options.

Using rodents for research shows that health problems in the womb can cause diseases later in life.

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

Tadalafil is effective for treating urinary symptoms in men with BPH.

Melasma is a skin condition linked to female hormones, genetics, UV exposure, and certain medications, but not to pituitary, adrenal, or thyroid diseases.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

Acne can be managed with various treatments and requires psychological support due to its emotional impact.

Hyperpigmentation is common in pregnancy and may not fully fade after birth; melasma, also frequent, can persist but has limited treatment options during pregnancy.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

Androgen use may increase the risk of stroke, but more research is needed.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Minoxidil can reduce functions related to androgen receptors.

Sex hormones may affect COVID-19 severity, with estrogen possibly reducing risk and testosterone potentially increasing it.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

Taking 5 mg/day finasteride can cause side effects in women with hair loss, but these are usually mild and fade over time, making the treatment beneficial in the long run.

The guidelines help doctors diagnose and treat hormone-related disorders in women.

Neuroactive steroids and the enzyme 5α-reductase might be involved in the development of Tourette's syndrome.