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The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Treating non-classic congenital adrenal hyperplasia is complex because the benefits of hormone treatment must be weighed against potential health risks.

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

Some antiandrogens may lower testosterone better than others, but it's unclear which is best for feminization in transgender women; more research is needed.

New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.

A new method accurately measures nine specific hormones in human blood.

Statins may help treat PCOS by lowering androgen levels and improving cholesterol.

Hirsutism is when women have too much hair growth, often due to a bit more androgen hormones and sensitive skin.

Overweight women with PCOS are more likely to have excess male hormones.

Eating a Mediterranean diet and taking certain supplements may improve symptoms of PCOS.

Polycystic ovary syndrome causes high male hormone levels, leading to symptoms like excess hair, acne, and fertility problems.

Some people experience lasting sexual, psychological, and sleep problems after using finasteride or SSRI antidepressants, possibly due to similar underlying causes.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

Early treatment and weight management are important for teenagers with PCOS to reduce symptoms and long-term health risks.

Sex hormones affect hair growth and loss, and treatments for related hair diseases include various medications, hair transplantation, and light therapy.

The document concluded that more research is needed to understand how estrogen affects the enzyme involved in hirsutism development.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

New treatments for enlarged prostate are being developed, some of which may be more effective than current medications.

Many potential alopecia treatments need more testing to confirm they promote acceptable hair growth with minimal side effects.

MicroRNAs could be key biomarkers and therapeutic targets for PCOS.

Flutamide and a new synthetic steroid affected brain and prostate chemicals and showed potential for treating androgen-related conditions and epilepsy.

Compound 7b is a promising candidate for treating benign prostatic hyperplasia and prostate cancer.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

Androgens, like DHT, affect hair growth and treatments like finasteride may help.

DHT, a testosterone byproduct, causes male pattern baldness.

Steroidogenic isoenzymes may help improve treatments for common hair loss.

Putting ketoconazole on the skin can help mice grow hair.

The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.