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11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Girls with PCOS have higher levels of certain androgens, which are linked to excess hair growth, but these androgens don't help diagnose PCOS.

Adolescents with PCOS have higher levels of certain androgens, which are linked to hair growth but don't help diagnose PCOS better than testosterone levels.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Finasteride lowers DHT levels and raises testosterone in a dose-dependent way.

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

Some women with PCOS have CYP21 mutations and IRS1 variants, but these genetic factors are not major contributors to PCOS.

Women's ovarian hormones and adrenal androgens change throughout life, affecting hair loss and health.

The N363S gene variant does not cause higher adrenal androgen levels in women with polycystic ovary syndrome.

Changes in gut bacteria can contribute to the development of Polycystic Ovary Syndrome (PCOS), affecting metabolism, immunity, and causing inflammation. Treatments may involve adjusting these factors.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

The method can measure multiple steroids in human hair to study long-term steroid metabolism, especially in newborns and children.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

The guide recommends specific methods for diagnosing PCOS and various treatments for its symptoms, while considering the health impacts on adolescents.

The document concludes that a systematic approach is crucial to identify causes of androgen excess in women beyond the most common cause, Polycystic ovary syndrome (PCOS).

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

Cyproterone acetate is effective for treating hirsutism and acne but less so for hair loss, with side effects similar to birth control pills.

Testosterone reduces heart damage and inflammation after injury.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.

Diagnosing hyperandrogenism in women is complex and requires accurate testing methods and consideration of SHBG levels.

New hormonal treatments for enlarged prostate show promise for safer, effective non-surgical options.

The document concludes that patient outcomes for Congenital Adrenal Hyperplasia are often not ideal because of poor management and a need for better diagnosis and treatment methods.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

Most women referred for excess male hormone symptoms had polycystic ovary syndrome (PCOS), with other conditions being less common.

Fulvestrant is a well-tolerated new treatment for advanced breast cancer that may delay chemotherapy.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.