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research Repigmentation Competence in Vitiligo: Integrating Immune, Regulatory, Regenerative, and Microenvironmental Axes

August 2026 in “Journal of Personalized Medicine”

This narrative review proposes the concept of "repigmentation competence" for vitiligo lesions, suggesting that therapy responses are influenced by lesion-specific biological factors related to immune, regenerative, regulatory, and microenvironmental processes, and highlights the emerging role of combination therapies targeting these pathways.

research LB1774 Establishing competent morphogenetic fields for tissue pattern regeneration in skin organoids

August 2023 in “Journal of Investigative Dermatology”

Skin organoids can regenerate hair by forming specific cell units with certain signals.

research Effect of site of defect on completeness of regeneration of the rat's skin

November 1971 in “Bulletin of Experimental Biology and Medicine”

The location of a skin injury affects how well a rat's skin can heal.

research Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing

128 citations , August 2020 in “Cell stem cell”

In this study, researchers found that extrafollicular progenitors marked by Hic1 are the main contributors to reparative fibroblasts in wound repair, with potential to modulate healing outcomes through genetic and pharmacological interventions.

research Engineering immune-competent hair follicle microphysiological systems: from organoid assembly to dynamic immune modelling

June 2026 in “Frontiers in Bioengineering and Biotechnology”

This review outlines the transition from simple hair follicle organoids to immune-competent microphysiological systems, addressing limitations in replicating native hair follicle immune features and discussing their applications in disease modeling and regenerative medicine.

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Community Join

5 / 304 results

community Modifiability of the aging process

17 upvotes 4 months ago

Hair loss is largely influenced by genetics, with treatments like finasteride, minoxidil, and RU58841 being used to manage it. Despite healthy lifestyles, hair loss can still occur, highlighting the complex relationship between genetics, health, and aging.

community What do you guys think about Stem cell treatments

4 upvotes 5 years ago

Stem cell and exosome injections for hair loss are discussed, with skepticism about their effectiveness and concerns about using non-genetically related stem cells. Dr. Deyarmin's treatments are mentioned, with some users questioning their legitimacy and others expressing curiosity.

community Can we get a reality check on PP405?

79 upvotes 11 months ago

PP405 is a promising hair loss treatment that may outperform minoxidil and finasteride by reviving dormant follicles and promoting significant regrowth. Results from ongoing trials are awaited, with a potential market release between 2028-2030.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

192 upvotes 4 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

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Learn

5 / 801 results

learn Redensyl

Does Redensyl regenerate follicles or only strengthen existing hair? Redensyl primarily strengthens existing hair rather than regenerating new follicles.

learn Exosomes

What are exosomes and how do they help regenerate hair in cases of severe hair loss? Exosomes are tiny vesicles that promote hair regeneration by signaling hair follicle cells.

learn Verteporfin

What is Verteporfin, and why is it being studied for hair follicle regeneration? Verteporfin is being studied for hair follicle regeneration due to its ability to inhibit YAP, promoting tissue healing.

learn Rosemary

Rosemary helps circulation, but does that actually regenerate hair? Rosemary may improve circulation but does not directly regenerate hair.

learn Thymosin Beta 4

What is Thymosin Beta 4, and why is it being researched in relation to hair follicle function and regeneration? Thymosin Beta 4 is a peptide being researched for its potential to enhance hair follicle regeneration.

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Clinics

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7
Hair TransplantHair Loss Treatments
derma competence center - Dr. med. Hero SchnitzlerZürich · CH

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