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    Research 10 of 1000+

    1. Immunohistochemical localization of types 1 and 2 5α-reductase in human scalp British Journal of Dermatology · 1999 · 100 citations
    2. The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression Korean Journal of Urology · 2014 · 75 citations
    3. 5α-Reductase inhibitor therapy: Should physicians be concerned with persistent diminished libido, erectile dysfunction and depression in a subset of patients? Journal of Men's Health · 2010
    4. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997 · 416 citations
    5. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor 2004 · 408 citations
    6. 5α-reductase activity in the prostate Urology · 2001 · 237 citations
    7. DIHYDROTESTOSTERONE AND THE PROSTATE: THE SCIENTIFIC RATIONALE FOR 5α-REDUCTASE INHIBITORS IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA 2004 · 235 citations
    8. Adverse Side Effects of 5α‐Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010 · 223 citations
    9. An overview on 5α-reductase inhibitors Steroids · 2009 · 219 citations
    10. The importance of dual 5α-reductase inhibition in the treatment of male pattern hair loss: Results of a randomized placebo-controlled study of dutasteride versus finasteride Journal of The American Academy of Dermatology · 2006 · 215 citations
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    Community 10 of 292

    1. Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction Reddit · 15 Jul 2026
    2. Supposedly dairy contains precursors to DHT that are already 5a-reduced and convert to DHT independent of 5a-reductase inhibition Reddit · 15 Apr 2026
    3. FCE 28260: A Forgotten 5α-Reductase Inhibitor Community · 22 Aug 2024
    4. 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that? Reddit · 3 Oct 2024
    5. Did anybody use beta sisterol for hair loss? I saw in many articles in the internet that said that beta sisterol blocks dht by inhibiting 5a reductase type 2 enzyme and some reviews of people who said that it worked better than saw palmetto in terms of stoping hair loss and helping prostate. Reddit · 11 May 2023
    6. Which Saw Palmetto is good for blocking 5 alpha reductase, Serenoa repens or Chamaerops humilis? Reddit · 26 Jun 2020
    7. Does caffeine inhibit 5-α-reductase? Reddit · 27 Dec 2019
    8. Does anyone know about the mechanism between creatine and 5-alpha reductase? Reddit · 25 Mar 2019
    9. M34- 1 year Progress- I Was reluctant at first but then went for it and got good results. I'm more than satisfied. Reddit · 2 Jul 2026
    10. How concerned should I be about the Testosterone (and thus resultant DHT) spike from Ashwagandha, as a Dutasteride user? Reddit · 22 Mar 2022
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    Learn 2 of 6

    1. Finasteride Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically
    2. Dutasteride 5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride
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