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research Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men

31 citations , January 2017 in “Advances in Experimental Medicine and Biology”

This review discusses the negative health impacts of testosterone deficiency and the potential adverse effects of 5α-reductase inhibitors, emphasizing the need for patient-physician discussions regarding these treatments.

research Myocyte Androgen Receptor Modulates Body Composition and Metabolic Parameters

December 2010 in “TSpace”

In this study, selective overexpression of androgen receptors in muscle cells increased lean muscle mass and reduced fat mass in transgenic rodents, suggesting a potential target for drug development.

research Drug Therapy in Polycystic Ovarian Syndrome

November 2003 in “Aap Grand Rounds”

This study found that a combination of low-dose flutamide and metformin therapy may reverse insulin resistance and reduce fat mass in nonobese adolescents with PCOS.

research Body composition and physical fitness in transgender versus cisgender individuals: a systematic review with meta-analysis

February 2026 in “British Journal of Sports Medicine”

Transgender women have similar fitness to cisgender women, while transgender men have higher fat and lower strength than cisgender men; hormone therapy affects body composition and strength.

research Effects of Intramuscular Testosterone Undecanoate on Body Composition and Bone Mineral Density in Female-to-Male Transsexuals

105 citations , June 2010 in “The journal of sexual medicine”

In this study, female-to-male transsexuals treated with long-acting testosterone undecanoate experienced an increase in lean mass but no change in fat mass or bone mineral density over 24 months.

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community How do you keep your bloodsugar low on finasteride?

12 upvotes 2 years ago

Finasteride may affect blood sugar and metabolism, with some users reporting increased blood sugar and changes in body composition. To manage potential side effects, users suggest exercise, intermittent fasting, and dietary adjustments.

community Been on Propecia since 1997, recently switched to Topical Finasteride.. follow for updates, or to ask any questions about 23 years on Propecia.

103 upvotes 5 years ago

User spent 23 years on Finasteride with side effects like weight gain and reduced libido. Switched to topical Finasteride, side effects reduced and waiting for results.

community My experience with dutasteride 4.5 months and oral minoxidil 1.5 months so far

in Finasteride/Dutasteride 10 upvotes 5 years ago

The user switched from finasteride to dutasteride and added oral minoxidil, which helped regrow their hairline and reduce shedding. They experienced side effects like brain fog, sluggishness, and fat gain with dutasteride, and slight chest tightness with oral minoxidil.

community The Fear of Oral Minoxidil is Overblown

272 upvotes 1 year ago

Low-dose oral minoxidil is a safe and effective hair loss treatment with fewer side effects than previously feared. Users often prefer it over topical minoxidil for better results, though some experience side effects like increased body hair and cardiovascular issues.

community Results are in for my experiment with Creatine/Fin

129 upvotes 6 years ago

Creatine use with finasteride increased DHT levels, possibly affecting hair loss. The user plans to reduce creatine to stabilize DHT and hair shedding.

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