September 2025 in “medRxiv (Cold Spring Harbor Laboratory)” This study found that applying a topical scalp essence with Centella asiatica extracellular vesicles and growth factors significantly improved scalp health and hair growth compared to a placebo after 56 days.
This study found that recombinant human type XVII collagen (rhCOL17A1) promotes hair growth by activating the Wnt/β-catenin and SHH/GLI signaling pathways and increasing type XVII collagen expression, with significant effects observed in both cell and mouse models.
November 2025 in “Cosmetics” In this exploratory randomized controlled trial, participants using a combination of Centella asiatica-derived extracellular vesicles with recombinant growth factors showed significant improvements in hair thickness, density, length, and reduced hair loss and scalp sebum content after 56 days, compared to placebo.
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September 2019 in “British Journal of Dermatology” This study found that a novel peptide, FOL-005, derived from osteopontin, significantly inhibited hair growth in human hair follicles both ex vivo and in vivo, suggesting potential as a treatment for unwanted hair growth.
August 2021 in “Chinese journal of burns” This study found that combining FUE transplantation with rb-bFGF gel and minoxidil tincture significantly improved hair survival, reduced hair loss, and increased patient satisfaction in cicatricial alopecia treatment, compared to FUE alone, with fewer adverse effects reported within 12 months post-surgery.
