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Did you mean ERK Signaling Pathway?

GlossaryERK Pathway (ERK Signaling Pathway)

chain of proteins transmitting signals from cell surface to DNA

The ERK Pathway, also known as the Extracellular Signal-Regulated Kinase Pathway, is a chain of proteins in the cell that communicates signals from a receptor on the cell's surface to the DNA in the nucleus. This pathway plays a crucial role in regulating various cellular activities, including growth, division, and differentiation. It is particularly important in the context of hair biology, as disruptions in this pathway can influence hair growth and contribute to conditions like alopecia.

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research Sorafenib-Induced Eruption Resembling Pityriasis Rubra Pilaris

21 citations , July 2011 in “Journal of the American Academy of Dermatology”

A man developed a rash similar to pityriasis rubra pilaris after starting sorafenib for cancer, possibly due to the drug's effect on skin cells.

Mechanisms of Cutaneous Adverse Events During Targeted Cancer Therapy

research Mechanisms of Cutaneous Adverse Events During Targeted Cancer Therapy

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Targeted cancer therapies can cause skin side effects, but activating SOS in the skin may help reduce them.

research Abstract 1677: Epithelial Hyperplasia Induced by a Selective B-Raf Inhibitor, WYE-130600

1 citations , April 2010 in “Cancer Research”

WYE-130600 may cause skin thickening and irritation.

The Incidence and Management of Cutaneous Adverse Events of the Epidermal Growth Factor Receptor Inhibitors

research The Incidence and Management of Cutaneous Adverse Events of the Epidermal Growth Factor Receptor Inhibitors

18 citations , January 2017 in “Postępy Dermatologii i Alergologii”

EGFR inhibitors can cause various skin issues during cancer treatment, and managing these is important for patient care.

research Continuous MEK Inhibition by AZD6244 Results in Exhaustion of the Cutaneous Keratinocytic Stem Cell Pool and Resembles Senescence Driven Skin Aging

2 citations , May 2008 in “Journal of Clinical Oncology”

AZD6244 treatment causes skin aging effects by depleting skin stem cells.

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