research Replicative Stress, Stem Cells, and Aging
Maintaining DNA health in stem cells is key to preventing aging and tissue breakdown.
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research Promotion of Homology-Directed DNA Repair by Polyamines
Polyamines help fix DNA damage accurately in cells.
research Abstract 2474: The Mechanistic Role of Polyamines in DNA Double-Strand Break Repair
The study explored the role of polyamines in DNA double-strand break (DSB) repair, particularly focusing on their involvement in the homologous recombination (HR) repair pathway rather than non-homologous end joining (NHEJ). It was found that polyamines enhance the RAD51-mediated DNA strand exchange reaction by improving duplex DNA capture, which is crucial for the repair process. The research utilized biochemical analyses, cell-based experiments, and an animal model using mouse hair follicles to demonstrate the physiological significance of polyamines in DNA repair. These findings provided valuable insights into the mechanistic role of polyamines in DNA repair, highlighting their potential impact on tumorigenesis due to their increased levels in many cancers.
research Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice
Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.
research ATP-Competitive mTOR Kinase Inhibitors Delay Plant Growth by Triggering Early Differentiation of Meristematic Cells Without Developmental Patterning Change
Certain inhibitors slow down plant growth by causing early cell specialization without changing the cell development pattern.
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