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research Selective non-steroidal inhibitors of 5α-reductase type 1

49 citations , January 2004 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

This review discusses the development and selectivity of 5 alpha-reductase inhibitors, particularly non-steroidal ones, and reports no new clinical trial results.

Expression of Type 1 5α-Reductase and Metabolism of Testosterone in Reconstructed Human Epidermis: A New Model for Screening Skin-Targeted Androgen Modulators

research Expression of type 1 5α-reductase and metabolism of testosterone in reconstructed human epidermis (SkinEthic®): a new model for screening skin-targeted androgen modulators

3 citations , December 2000 in “International Journal of Cosmetic Science”

This study established that a human epidermal model can be utilized to assess 5alpha-reductase activity and evaluate enzyme modulators, such as finasteride, for dermatological applications.

research A new label-free screen for steroid 5α-reductase inhibitors using LC-MS

15 citations , October 2016 in “Steroids”

This study developed and validated a label-free assay using LC-MS to screen for S5αR inhibitors, identifying Thai herbal extracts, Impatiens balsamina L. and Curcuma longa L., as promising sources.

research Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases

11 citations , February 2016 in “Current Medicinal Chemistry”

This review discusses various targets for treating prostate cancer and benign prostatic hyperplasia and reports on recent studies of new compounds and 5α-reductase inhibitors, but provides no new experimental results.

research Androgens and alopecia

165 citations , December 2002 in “Molecular and Cellular Endocrinology”

This study found that finasteride improves scalp hair growth in men with male pattern hair loss by reducing scalp dihydrotestosterone levels, but it did not benefit postmenopausal women with female pattern hair loss.

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