4 citations
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December 2022 in “Evidence-based Complementary and Alternative Medicine” This study found that phenolic compounds from Quercus acutissima, particularly casuarinin, showed strong antioxidative, anti-inflammatory, and antiacne effects in mouse macrophage cells, suggesting potential therapeutic candidates for acne.
37 citations
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January 2015 in “Evidence-based Complementary and Alternative Medicine” This study found that Bokusoku extract and its compound pentagalloyl glucose inhibited testosterone metabolism and sebum synthesis, suggesting potential therapeutic use for androgen-related acne.
17 citations
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March 2020 in “Frontiers in Chemistry” This study isolated new geranylated coumarins from Mammea siamensis flowers and found that several of these compounds inhibit testosterone 5α-reductase.
15 citations
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April 2022 in “Biointerface Research in Applied Chemistry” This review presents current evidence on medicinal plants and their phytoconstituents, such as phenolic compounds, used in acne treatment, highlighting their potential as alternatives to conventional therapies due to issues like antibiotic resistance and high cost.
11 citations
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December 2018 in “Assay and Drug Development Technologies” This review highlights the challenges in screening for steroid 5 alpha-reductase inhibitors and discusses significant variability in the effectiveness of finasteride and dutasteride, calling for standardized testing methods to develop safer, more specific inhibitors from herbal preparations.