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HPLC Characterization, Molecular Docking, QSAR and Molecular Dynamics Simulation of Alstonia Boonei Phytochemical Analogs as Potent 5-Alpha Reductase Inhibitors

research HPLC Characterization, Molecular Docking, QSAR and Molecular Dynamics Simulation of Alstonia Boonei Phytochemical Analogs as Potent 5-Alpha Reductase Inhibitors

2 citations , July 2025 in “Discover Chemistry.”

Alstonia boonei phytochemicals show promise as alternative treatments for BPH with fewer side effects than current drugs.

research QSAR Analysis of a Series of Hydantoin-Based Androgen Receptor Modulators and Corresponding Binding Affinities

April 2019 in “Molecular Informatics”

Researchers developed reliable models to predict how well certain compounds bind to androgen receptors, emphasizing the importance of atomic electronegativity.

research Pharmacophore and Atom-Based 3D QSAR Studies on the Novel 5-Alpha-Reductase Inhibitors

2 citations , November 2018 in “Indian Journal of Pharmaceutical Education”

The developed model can predict effective 5-alpha-reductase enzyme inhibitors.

Drug Discovery Insights from a Computational QSAR Study on Alpha-Reductase Inhibitors and Layered Double Hydroxides Electrocatalysts

research Drug Discovery Insights from a Computational QSAR Study on Alpha-Reductase Inhibitors and Layered Double Hydroxides Electrocatalysts

March 2025 in “International Journal For Multidisciplinary Research”

Computational techniques can improve drug development for treating certain conditions.

research Generation of Comparative Pharmacophoric Model for Steroidal 5α-Reductase I and II Inhibitors: A 3D-QSAR Study on 6-Azasteroids

13 citations , January 2015 in “Steroids”

The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.

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community Dutasteride actually has different half lives depending on dose

in Research/Science 37 upvotes 9 months ago

Dutasteride's half-life varies with dosage, and lower doses can be effective with fewer side effects compared to finasteride. Some users report different side effects with dutasteride and finasteride, and extreme dosages of dutasteride are unnecessary and potentially harmful.