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research Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue

10 citations , June 2018 in “Journal of visualized experiments”

This study demonstrated that lactate dehydrogenase activity is notably high in quiescent hair follicle stem cells within mouse skin using a specific enzymatic activity assay.

research Lactate dehydrogenase activity drives hair follicle stem cell activation

202 citations , August 2017 in “Nature cell biology”

This study found that glycolytic metabolism and lactate production are crucial for hair follicle stem cell activation, and manipulating these processes can stimulate the hair cycle.

research Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets

3 citations , May 2022 in “Experimental Dermatology”

This review discusses the role of hair follicle stem cell metabolism, ageing, and microenvironment in hair growth disorders and compiles recent research on using stem cell-based regenerative medicine for treating alopecia, without reporting new clinical results.

research The Force Is Strong with This One: Metabolism (Over)powers Stem Cell Fate

33 citations , March 2018 in “Trends in cell biology”

This review summarizes evidence suggesting that metabolism actively influences stem cell fate in intestinal and hair follicle stem cells, rather than being a mere environmental byproduct.

research Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin

36 citations , January 2019 in “Nature communications”

This study found that Ldh activity in hair follicle stem cell-mediated squamous cell carcinoma is not necessary for tumorigenesis, as its modulation did not affect the cancer's development or characteristics.

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community Anyone heard of scube3? And other emerging treatments?

in Research/Science 4 upvotes 1 year ago

Emerging hair loss treatments like PP405, a topical MPC inhibitor, show promise in activating stem cells for hair growth. The conversation seeks information on the development stages and accessibility of these treatments.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

484 upvotes 2 years ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community The Cure isn't 5 years away; it's already here.

in Research/Science 1005 upvotes 1 year ago

PP405 is a new topical treatment for hair loss, showing promise in trials but still requires finasteride for maintenance. There is skepticism about its effectiveness and safety, with concerns about needing finasteride to maintain results.

community Story time! The Great Unbalding (PP405)

230 upvotes 11 months ago

PP405 is a promising new hair loss treatment that may reactivate dormant hair follicles without side effects. It could surpass traditional treatments like minoxidil and finasteride if successful in further trials.

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learn PP405

mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

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