29 citations
,
February 2019 in “Environment international” This study found that higher prenatal and early childhood lead exposure may be associated with delayed pubertal development in girls, but not in boys, in Mexico City.
192 citations
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January 1976 in “The Journal of Clinical Endocrinology & Metabolism” This study observed that androgen levels rise with pubic hair development in Tanner stages, differing by sex and age, with DHEA showing a significant prepubertal increase especially in precocious adrenarche.
19 citations
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March 2004 in “The Journal of Clinical Endocrinology & Metabolism” This study suggests that combining testosterone and letrozole may accelerate puberty in boys with constitutional delay by increasing serum androgen bioactivity and facilitating pubertal progression.
30 citations
,
March 1980 in “European Journal of Endocrinology” This study suggests that genetic factors significantly influence adrenal androgen levels and the progression of puberty, with adrenal cortex maturation appearing independent of the hypothalamic-pituitary-gonadal axis.
3 citations
,
June 2017 in “Deep Blue (University of Michigan)” This study found that prenatal exposure to fluoride and lead, as well as maternal micronutrient intake, may influence sexual maturation in adolescents in a sex-specific manner.