April 2018 in “Journal of Investigative Dermatology” This study used single-cell RNA sequencing to identify at least nine subpopulations of keratinocytes in human neonatal epidermis, revealing unexpected heterogeneity and complex differentiation trajectories.
November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers mapped gene expression in developing hair follicles to reveal unknown cell populations and markers, suggesting early establishment of cell fates in hair placodes.
1 citations
,
November 2020 in “Biochemical Society transactions” This narrative review discusses the discovery of plasticity in epidermal stem cells using single-cell transcriptomics, but reports no new results; it highlights the potential implications for regenerative medicine.
3 citations
,
September 2024 in “International Journal of Molecular Sciences” This review examines how mathematical modeling of the MAPK pathway, enhanced by single-cell proteomic data, improves understanding of regulatory mechanisms, predicts system behavior, and guides experimental research, emphasizing recent developments in modeling and inference.
This study found that GPC1 is a key regulator of angiogenesis in hair follicles and may be an interesting target for addressing alopecia in dermatology research.