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      Post-Finasteride Syndrome: An Underestimated Phenomenon

      research Post-Finasteride Syndrome: An Underestimated Phenomenon

      May 2017 in “Urology and andrology”
      Finasteride and dutasteride, used for prostate issues and hair loss, can cause side effects like sexual dysfunction and mental issues, which may continue even after stopping the medication, a condition called post-finasteride syndrome, for which there's currently no cure.
      Finasteride

      research Finasteride

      86 citations , July 1993 in “Drugs”
      Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

      research 5alpha-reductase: history and clinical importance.

      62 citations , January 2004 in “PubMed”
      This review describes the shift in treating symptomatic benign prostatic hyperplasia from surgery to 5alpha-reductase inhibitor drugs, which may provide symptom relief and alter BPH's progression, but reports no new clinical results.

      research 5α-Reductase: History and Clinical Importance

      20 citations , January 2004 in “PubMed Central”
      This article reviews the use of 5α-reductase inhibitors for treating benign prostatic hyperplasia, suggesting potential benefits beyond symptom relief, but it reports no new clinical results.

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      learn Dutasteride

      • Will I notice changes in my body if I start taking dutasteride? Dutasteride lowers DHT, so labels and trials describe prostate shrinkage over 3-6 months and, off-label, slowed hair loss; the same sources list sexual side effects and an observational link to depression.
      • Dutasteride side effects: what the label and studies actually report The Avodart label reports impotence in 4.7% and decreased libido in 3.0% of men in the first six months (1.7% and 1.4% on placebo), with new reports falling after month six; those figures come from BPH trials in older men, and the hair-loss trials in younger men run only six months. The label and studies also flag a PSA drop of about half, a small rise in high-grade prostate cancer in one trial, an observational link to depression, and sexual effects that the label says may persist after stopping.