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5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder

research 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder

110 citations, August 2015 in “Neuropsychopharmacology”

High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.

Are There Temporal Subtypes of Premenstrual Dysphoric Disorder? Using Group-Based Trajectory Modeling to Identify Individual Differences in Symptom Change

research Are There Temporal Subtypes of Premenstrual Dysphoric Disorder? Using Group-Based Trajectory Modeling to Identify Individual Differences in Symptom Change

19 citations, April 2020 in “Psychological Medicine”

The study found three different timing patterns of symptoms in women with premenstrual dysphoric disorder.

research Double Dosing

2 citations, October 2002 in “American Journal of Nursing”

Taking the same medication under different brand names caused harmful side effects.

research Psychotropic Treatment of Psychodermatologic Disorders

3 citations, January 2010 in “Actas Dermo-Sifiliográficas”

Psychotropic drugs can help treat skin conditions affected by mental health, but dermatologists must use them carefully due to side effects and patient concerns.

research Neurosteroids, Neuroactive Steroids, and Symptoms of Affective Disorders

82 citations, August 2006 in “Pharmacology, Biochemistry and Behavior”

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

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community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 5 months ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community Proof that finasteride messes with neurosteroids

in Research/Science 230 upvotes 5 months ago

Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.