192 citations
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January 1976 in “The Journal of Clinical Endocrinology & Metabolism” This study observed that androgen levels rise with pubic hair development in Tanner stages, differing by sex and age, with DHEA showing a significant prepubertal increase especially in precocious adrenarche.
31 citations
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January 2018 in “Pediatric annals” This article reviews the characteristics, diagnosis, and management of premature adrenarche and suggests it may predict future ovarian hyperandrogenism in some adolescents; no new clinical results are reported.
June 2025 in “V F Snegirev Archives of Obstetrics and Gynecology” In this case study, a six-year-old girl was diagnosed with isolated adrenarche, linked to premature adrenal maturation, with increased dehydroepiandrosterone sulfate and axillary and pubic hair growth, and will require long-term monitoring due to increased risks of conditions like polycystic ovary syndrome and cardiovascular diseases.
May 2016 in “Journal of pediatric nursing” This case report highlights the need to consider complementary and alternative medicine use in endocrine evaluations, as stopping lavender oil use coincided with normalization of a concerning lab finding in a girl with precocious puberty signs.
October 2022 in “Medical Clinical Update Journal” This case report describes a 7.5-year-old girl with precocious puberty displaying significant secondary sexual development and advanced bone age, treated monthly with Leuprolide.