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research Role of skin microbiome and exosomes in Hair regeneration and disorders in diseases like Alopecia, Acne: A comprehensive review

February 2026 in “International Journal of Web of Multidisciplinary Studies”

This review synthesizes current research on how the interaction between the skin microbiome and exosome-mediated communication influences hair disorders, and discusses how microbiome restoration and exosome-based therapies could advance treatments for conditions like alopecia by promoting hair regrowth and follicular health.

research 397 Predictive modeling of drug response and mechanism of action in alopecia areata clinical trials

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, distinct molecular mechanisms of action were identified for three drugs used in alopecia areata clinical trials, providing insights for precision medicine and treatment selection.

research COVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine

58 citations , December 2020 in “Mayo Clinic Proceedings”

This paper discusses the variability in COVID-19 susceptibility and severity, emphasizing factors like biological differences and suggesting potential precision medicine approaches, but it reports no new clinical results.

research No difference in the proteome of racially and geometrically classified scalp hair sample from a South African cohort: Preliminary findings

4 citations , July 2020 in “Journal of proteomics”

This study found no significant proteomic differences in hair samples across racial or geometric groups in a culturally diverse South African cohort, highlighting the limited value of racial classification in precision medicine.

research Rethinking pattern hair loss classification in the era of trichoscopy and artificial intelligence

March 2026 in “Frontiers in Medicine”

This study suggests that traditional classification systems for pattern hair loss, while useful in the past, have limitations in accuracy and reproducibility, and highlights the potential of integrating digital imaging and AI to create more precise and biologically informed classification frameworks.

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Community Join

5 / 47 results

community Are there actual risks with oral minoxidil? How can they be mitigated

in Minoxidil 20 upvotes 6 months ago

Oral minoxidil can cause side effects like heart issues, increased body hair, and facial puffiness, but these are often dose-dependent and temporary. Users report varying experiences, with some combining it with finasteride or RU58841 for better results, while others experience minimal or no side effects.

community 5 months topical spiro + minox + micro

6 upvotes 1 year ago

A 35-year-old male uses topical minoxidil, spironolactone, and microneedling for hair loss, with spironolactone prescribed based on a DNA test indicating poor response to finasteride and dutasteride. Despite concerns about the test's validity and spironolactone's side effects, he reports stable or improved hair condition and no low testosterone symptoms.

community Why the cure is not yet found and why it is always 5 years away? Why no hopes on PP405, GT, KX, Hair cloning, AMP, etc, etc, etc

19 upvotes 1 year ago

Skepticism about hair loss research motivations, suggesting financial interests hinder finding a cure. Mentions treatments like minoxidil, finasteride, and dutasteride, but notes they are not cures.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

158 upvotes 2 years ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

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