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Progesterone-Independent Neurosteroid Regulation of Alpha2-GABA-A Receptors in the Hippocampus Subfields

research PR-independent neurosteroid regulation of α2-GABA-A receptors in the hippocampus subfields

14 citations , March 2017 in “Brain research”

This study suggests that ovarian cycle-related progesterone and neurosteroids regulate α2-subunit expression of GABA-A receptors in the hippocampus through a pathway independent of progesterone receptors, potentially affecting brain conditions linked to the menstrual cycle.

research Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice

76 citations , April 2013 in “PLoS ONE”

The researchers reported that reactive oxygen species regulate the stress-induced SP-Mast cell pathway, which might support using antioxidants to treat stress-related hair loss.

Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P

research Indications for a brain‐hair follicle axis: inhibition of keratinocyte proliferation and up‐regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P

125 citations , September 2001 in “The FASEB Journal”

This study demonstrated that stress inhibited hair growth in mice, likely through substance P-dependent activation of immune cells, highlighting a brain-hair follicle connection.

research Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice

180 citations , June 2004 in “Journal of Pharmacology and Experimental Therapeutics”

This study found that progesterone's antiseizure effects in mice occurred primarily through conversion to allopregnanolone, rather than through the progesterone receptor, as evidenced by results in PR knockout mice.

research Norepinephrine Regulates Keratinocyte Proliferation to Promote the Growth of Hair Follicles

8 citations , January 2016 in “Cells tissues organs”

This study found that chemical sympathectomy inhibited hair follicle growth in mice, suggesting that sympathetic nerves may regulate keratinocyte behavior to promote hair growth.

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Community Join

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community They’re curing cancer before solving baldness

285 upvotes 4 weeks ago

The conversation humorously discusses the prioritization of curing cancer over solving baldness, with mentions of treatments like finasteride and dutasteride. Participants express frustration over the lack of focus on hair loss solutions compared to cancer research.

community PSA: If you're prone to MPB dont take creatine

103 upvotes 3 years ago

Creatine might speed up hair loss in those prone to male pattern baldness, possibly due to increased DHT levels. Some users experience no issues when using creatine with treatments like finasteride, minoxidil, or dutasteride.

community Recommendations for topical saw palmetto / pumpkin seed oil product

2 upvotes 5 years ago

The user is seeking recommendations for topical saw palmetto and pumpkin seed oil products to treat early male pattern baldness and is considering different options available online. They are specifically asking which saw palmetto product to choose between two provided links.

community Why does Pelage PP405 receive so much attention, while Eirion ET-02 seems to be almost forgotten?

30 upvotes 1 year ago

ET-02 is seen as promising for addressing hair loss and graying, but PP405 is more advanced in development and has better publicity. Some users plan to use both treatments alongside minoxidil and dutasteride.

community What new hair-loss treatments actually look exciting right now (Oct 2025)

171 upvotes 11 months ago

New hair loss treatments include Breezula, PP405, ET-02, KX-826, GT20029, VDPHL01, and CosmeRNA, with some showing promise in reactivating stem cells and reversing greying. Breezula and VDPHL01 are highlighted as potential add-ons or alternatives to current treatments like finasteride and minoxidil.

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Nikol Prandota