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GlossaryPostpartum Hair Loss (Postnatal Hair Loss)

hormonal changes after childbirth cause temporary hair shedding

Postpartum Hair Loss, also known as Postpartum Alopecia, is a common condition where women experience significant hair shedding after giving birth. This occurs due to hormonal changes, particularly the drop in estrogen levels, which causes more hair follicles to enter the resting (telogen) phase and subsequently fall out. The shedding typically peaks around three to six months postpartum and usually resolves on its own within a year.

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research Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling

65 citations, September 2004 in “The American journal of pathology”

Blocking BMP signaling causes hair loss and disrupts hair growth cycles.

research Molecular Evolution of HR, a Gene That Regulates the Postnatal Cycle of the Hair Follicle

9 citations, July 2011 in “Scientific Reports”

Changes in the HR gene have influenced hair growth and may lead to hair loss conditions in humans.

Smad1 and Smad5 but Not Smad8 Establish Stem Cell Quiescence Critical for Transforming Premature Hair Follicles During Morphogenesis to the Postnatal State

research Smad1 and Smad5 but Not Smad8 Establish Stem Cell Quiescence Critical for Transforming Premature Hair Follicles During Morphogenesis to the Postnatal State

31 citations, September 2013 in “Stem Cells”

Smad1 and Smad5 are essential for hair follicle development and stem cell sleepiness.

research Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality

46 citations, December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Disrupting Acvr1b in mice causes severe hair loss and thicker skin.

research Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog

231 citations, October 1999 in “Journal of Clinical Investigation”

Activating the Sonic hedgehog gene in mice can start the hair growth phase.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Scalp tension and thickness of the galea aponeurotica, inflammation and potential treatment pathways

in Research/Science 2 years ago

Scalp tension potentially affecting hair loss, and potential treatments for male pattern baldness such as Minoxidil, Finasteride and RU58841. Evidence from a study was discussed which suggests that the cause of MPB lies within the follicle itself and is not dependent on its surrounding environment.

community Verteporfin and Microneedling

in Treatments 5 months ago

Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

community Opinions on Scalp fibrosis and DHT?

in Research/Science 9 upvotes 2 years ago

The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.