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research Profibrotic Subsets of SPP1+ Macrophages and POSTN+ Fibroblasts Contribute to Fibrotic Scarring in Acne Keloidalis

23 citations , January 2024 in “Journal of Investigative Dermatology”

In this study, researchers used advanced RNA sequencing techniques to discover that communication between specific fibroblast and myeloid cell populations may play a role in acne keloidalis, and found that corticosteroid injections could significantly reduce disease activity and gene expression related to these cells.

research Discovery Potential Hub Genes and Pathways in Keloid Fibroblast Development Based on Bioinformatics Analysis

January 2025 in “International Journal of Genomics”

This study identified three hub genes—BMP4, POSTN, and WNT5A—that are closely associated with keloid fibroblast hyperplasia, suggesting they may serve as potential biomarkers for inhibiting this condition. Further research is necessary to fully understand their roles in keloid development.

research Updated Management of Atrophic Post Acne Scars: Review Article

October 2021 in “The Egyptian Journal of Hospital Medicine ”

This study concluded that combination therapies often yield better results for treating atrophic post-acne scars than single treatments.

Epigenetic Orchestration of RNA m6A Methylation in Wound Healing and Post-Wound Events

research Epigenetic orchestration of RNA m⁶A methylation in wound healing and post-wound events

3 citations , July 2025 in “International Journal of Biological Sciences”

This review highlights that the RNA modification N⁶-methyladenosine (m⁶A) plays a crucial role in regulating wound healing and tissue remodeling, with dysregulation contributing to complications in chronic wounds, such as diabetic ulcers and burn injuries, through mechanisms like impaired angiogenesis and increased oxidative stress.

research In vitro Growth and Differentiation of Epithelial Cells derived from Post-embryonic Hair Follicles

7 citations , February 1982 in “Australian Journal of Biological Sciences”

This study observed that cell aggregates formed rapidly in cultures of rat hair follicle cells, with proteins showing hair cortical keratin but not synthesizing it as anticipated.

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community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?

32 upvotes 1 year ago

Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.

community Tazarotene shows strong standalone hair regrowth potential, not just a Minoxidil enhancer. Backed by VEGF, HF regeneration, and angiogenesis pathways. Here’s why.

135 upvotes 1 year ago

Tazarotene shows potential as a standalone treatment for hair regrowth by stimulating new hair follicle formation and promoting angiogenesis, similar to microneedling effects. It can be used topically without minoxidil, but users should start with a low concentration to avoid irritation.

community The most nuclear stack possible

45 upvotes 1 year ago

A user humorously suggests an extreme hair loss treatment regimen involving multiple medications and therapies, including Dutasteride, Minoxidil, RU58841, and others, claiming it would prevent hair loss but with potential side effects like gynecomastia. The conversation highlights concerns about safety, side effects, and the effectiveness of such a comprehensive approach.

community Growth factors, VEGF, And more,possible permanent cure for people with moderate hairloss?

3 upvotes 2 years ago

The user discusses using dutasteride to stop hair loss and bimatoprost for regrowth. They plan to use VEGF with hydrogels for potentially permanent hair follicle improvement and suggest PRP as an alternative.

community Crazy growth after adding ostrich oil + microneedling in 2 months. (already on treatment previously)

65 upvotes 4 weeks ago

The user experienced significant hair growth after adding ostrich oil and weekly microneedling to their existing treatment of topical dutasteride and minoxidil. They believe the combination of ostrich oil and microneedling contributed to the results, although some users suggest the increased microneedling frequency might be the main factor.

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Learn

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learn nonspecific group of Fibronectins

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Hair Transplant

What is post-operative care like? Post-operative care is crucial for recovery and graft survival after a hair transplant.
What post-transplant care is required? Follow prescribed medications, avoid trauma, and protect your scalp for optimal healing.
What are the post-operative care requirements for a hair transplant? Avoid strenuous activities, follow prescribed medications, and keep the area clean and protected.
All 4 questions on Hair Transplant →

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