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Women with acne after adolescence are more likely to have PCOS and should be checked for it.

This study found that women with post-adolescent acne experience marked menstrual irregularities, polycystic ovaries, androgenetic alopecia, hirsutism, and metabolic syndrome, but insulin resistance and dyslipidemia may not significantly contribute to their acne's pathogenesis.

In this review, serum clusterin is highlighted as a promising diagnostic and prognostic marker for post-adolescent acne, suggesting its potential role in the inflammatory and immunological processes of the condition, although its exact mechanisms remain to be fully understood.

This study found that women with postadolescent acne often exhibit symptoms of hyperandrogenism, such as hirsutism and androgenetic alopecia, but have minimal hormone profile abnormalities.

This study suggests that the gene rs27647 polymorphism may play a role in the pathogenesis of severe acne vulgaris in post-adolescent male patients.