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research Genome-Wide Association Meta-Analysis of Individuals of European Ancestry Identifies New Loci Explaining a Substantial Fraction of Hair Color Variation and Heritability

94 citations , April 2018 in “Nature Genetics”

New genetic locations explain much of hair color variation in Europeans.

research Polygenic Control of the Wavy Coat of the NCT Mouse: Involvement of an Intracisternal A Particle Insertional Mutation of the Protease, Serine 53 (Prss53) Gene, and a Modifier Gene

January 2022 in “Mammalian Genome”

The wavy coat in NCT mice is caused by multiple genes, including a mutation in the Prss53 gene.

research Use of Genetics in the Prediction of Success in Male Pattern Hair Loss Therapy and Mechanistic Studies

February 2026 in “Frontiers in Pharmacology”

Genetics can help tailor treatments for male pattern hair loss, improving outcomes like stabilization or modest regrowth.

research The Genetic Landscape of Androgenetic Alopecia: Current Knowledge and Future Perspectives

January 2026 in “Biology”

Androgenetic alopecia is influenced by multiple genes and pathways, with genetic risk varying by population, and personalized treatments are being explored.

research Genetic Basis of Alopecia Areata

40 citations , October 2012 in “Dermatologic clinics”

More research is needed to understand the genetic causes of Alopecia areata to develop better treatments.

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Community Join

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community Chromosome 20’s balding effects and why fin likely isn’t working for some.

in Treatment 96 upvotes 6 months ago

Finasteride is effective for DHT/AR-driven hair loss but not for chromosome 20-driven cases, where treatments like minoxidil, prostaglandin analogs, and low-level laser therapy may be more beneficial. Genetic testing can help determine the underlying cause of hair loss to tailor treatment effectively.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 447 upvotes 4 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community My Theory Of Androgenic Alopecia

in Research/Science 19 upvotes 4 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community After 11 Years On Finasteride, Unfortunately, Hair Is Starting To Thin Again. Does Hair Simply Get More Sensitive To DHT As You Age?

in Finasteride/Dutasteride 95 upvotes 1 year ago

After 11 years on Finasteride, a user's hair is thinning again, suggesting hair may become more sensitive to DHT with age. They plan to introduce Dutasteride once a week, as they cannot tolerate Minoxidil.

community I don’t think my hair loss is caused by DHT – quitting finasteride after 3 months (1 mg). Need opinions

in Finasteride/Dutasteride 1 month ago

The user plans to stop finasteride after three months, believing hair loss isn't due to DHT, and will continue with oral minoxidil, microneedling, and ketoconazole shampoo. They suspect stress and poor nutrition are the main causes and seek opinions on DHT blockers' effectiveness.

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