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research Mitochondrial DNA Variation in Human Hair Shafts Influenced by Physical Characteristics: A Massively Parallel Sequencing Analysis

July 2026 in “Genes”

The researchers reported that certain physical characteristics of hair shafts, such as length and color, may influence mtDNA read counts and degradation state when analyzed by massively parallel sequencing.

research Quantitation of human mitochondrial DNA and whole mtGenomes sequencing of fingernail/hair shaft samples

3 citations , February 2024 in “Forensic Sciences Research”

In this study, researchers found that massively parallel sequencing of mitochondrial DNA (mtDNA) can improve information recovery from forensic samples, with successful full region amplification possible from as few as 2,000 mtDNA copies, albeit with variability in heteroplasmy among hair samples from the same donor.

research Phenotypic heterogeneity in human genetic diseases: ultrasensitivity-mediated threshold effects as a unifying molecular mechanism

July 2023 in “Journal of Biomedical Science”

In this review, the authors emphasize that phenotypic heterogeneity in genetic systems and human diseases is influenced by stochastic fluctuation and network topology, proposing that ultrasensitivity and threshold effects explain this variability, which may inform strategies for preventing and treating genetic diseases.

research Selected abstracts from the 47th meeting of the Irish Endocrine Society Sligo, 24th & 25th November 2023

October 2024 in “Irish Journal of Medical Science (1971 -)”

Continuous glucose monitoring and GLP-1 receptor agonists improve diabetes management, but personalized care and education are crucial.

research Demethylation of ITGAV accelerates osteogenic differentiation in a blast-induced heterotopic ossification in vitro cell culture model

11 citations , December 2018 in “Bone”

This study found that a high-energy shock wave can increase osteogenic activities in human mesenchymal cells, offering insights into potential therapeutic targets for trauma-induced heterotopic ossification.

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community Any point in microneedling if I use oral minoxidil?

in Microneedling 8 upvotes 6 months ago

The conversation discusses the use of microneedling as a complementary treatment for hair loss alongside oral minoxidil and dutasteride. Opinions vary on its effectiveness, with some users supporting its benefits for hair growth and others questioning its efficacy without topical minoxidil.

community Any point in microneedling with RU?

in Microneedling 1 upvotes 1 year ago

Microneedling with RU58841 may not be necessary since RU works topically by occupying receptors before DHT binds. RU58841 is a topical anti-androgen.

community What's the point of finasteride if dutasteride exists?

43 upvotes 3 days ago

Finasteride is effective for hair loss with fewer side effects and quicker clearance compared to dutasteride, which is more potent but has a longer half-life and potentially more side effects. Users suggest starting with finasteride and considering dutasteride only if more hair retention is needed and side effects are manageable.

community at what point is it too late to start treatment? balding since 11

in Finasteride/Dutasteride 5 upvotes 2 months ago

A 20-year-old male, balding since age 11, is considering adding finasteride or dutasteride to his current minoxidil treatment. Users suggest it's not too late to start finasteride or dutasteride, as these are more effective for hormonal hair loss.

community Bryan Johnson and his Hair routine, what's the point?

in Hair Systems 24 upvotes 5 months ago

Dutasteride and high-dose Minoxidil are the primary treatments maintaining hair, with additional supplements and therapies like red light offering minimal extra benefit. The discussion criticizes promoting expensive hair care products when basic medications are doing most of the work.

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