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The Silver Locus Product (Silv/gp100/Pmel17) as a New Tool for the Analysis of Melanosome Transfer in Human Melanocyte–Keratinocyte Co-Culture

research The Silver Locus Product (Silv/gp100/Pmel17) as a New Tool for the Analysis of Melanosome Transfer in Human Melanocyte–Keratinocyte Co-Culture

68 citations , March 2008 in “Experimental dermatology”

The new assay can track and measure melanosome transfer between skin cells, confirming filopodia's role in this process.

research Pharmacological BACE1 and BACE2 Inhibition Induces Hair Depigmentation by Inhibiting PMEL17 Processing in Mice

58 citations , February 2016 in “Scientific reports”

Blocking BACE1 and BACE2 enzymes causes hair color loss in mice.

research The Auxin-Regulated CrRLK1L Kinase ERULUS Controls Cell Wall Composition During Root Hair Tip Growth

109 citations , February 2018 in “CB/Current biology”

ERULUS controls root hair growth by regulating cell wall composition and pectin activity.

research Grey, Curly, and Short-Haired Swiss Holstein Cattle Show Genetic Traces of the Simmental Breed

2 citations , September 2020 in “Schweizer Archiv für Tierheilkunde”

Swiss Holstein cattle with curly, short hair carry genes from the Simmental breed.

research Development of an Ex Vivo Human Skin Explant Model to Examine Candidate Gene Functions in the Hair Follicle and Epidermis

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

The model can effectively test gene functions and drug responses in human skin.

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community Pyrilutamide bulk powder purchasing

in Product 2 upvotes 6 months ago

Pyrilutamide is being used effectively for hair loss with no side effects, and the user is seeking a cheaper bulk supplier. Users discuss the difficulty of finding affordable, trustworthy sources, with some suggesting potential suppliers.

community Update July 2025] Most Promising Hair Loss Treatments in Clinical Trials

in Research/Science 265 upvotes 2 months ago

Promising hair loss treatments in clinical trials include Pyrilutamide, GT20029, CB-03-01, and PP405, with potential market releases between 2027 and 2029. Hair cloning remains experimental and expensive, while existing treatments like finasteride, minoxidil, and microneedling continue to be used.

community Completely defeated after trying so hard with topical finasteride.

in Finasteride/Dutasteride 24 upvotes 2 years ago

A user who has tried multiple treatments for hair loss, including oral and topical finasteride and liposomal finasteride, but experienced severe side effects in each case; the user is considering trying RU58841 or aromatise inhibitors as alternatives.

community 2 year progress on fin and minox

in Progress Pictures 1149 upvotes 5 years ago

A user's 2-year experience with Minoxidil and Finasteride as a treatment for hair loss, including the costs involved and potential side effects. Other users shared their experiences and asked questions about their own use of these treatments.