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Research

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research Effect of a novel steroid (PM-9) on the inhibition of 5α-reductase present in Penicillium crustosum broths

22 citations , March 2003 in “Steroids”

This study found that both finasteride and a new steroidal compound, PM-9, competitively inhibit the 5α-reductase enzyme in Penicillium crustosum broth.

research 5 alpha-reductase inhibition by a new synthetic steroid (PM-9) in cultures of Penicillium crustosum.

1 citations , January 2002 in “PubMed”

The researchers reported that both finasteride and PM-9 competitively inhibit the 5 alpha-reductase enzyme in P. crustosum broth.

research Formulation and Evaluation of Minoxidil Loaded Submicron Emulsion Based Topical Gel for Treatment of Alopecia

December 2023 in “Azerbaijan Pharmaceutical and Pharmacotherapy J”

This study formulated a minoxidil-loaded submicron emulsion-based topical gel, which demonstrated effective in vitro release, ex vivo permeation, and stability, suggesting it may offer a targeted treatment approach for alopecia compared to traditional methods.

research The PCOS Phenotypes in Unselected Populations (P-PUP) study: participant clinical features and data harmonization on analysis of individual participant data

1 citations , July 2025 in “BMC Medicine”

The authors concluded that establishing and standardizing methods for data collection are crucial to improving PCOS diagnosis and research due to challenges observed in data harmonization across diverse international cohorts.

research Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice

76 citations , April 2013 in “PLoS ONE”

The researchers reported that reactive oxygen species regulate the stress-induced SP-Mast cell pathway, which might support using antioxidants to treat stress-related hair loss.

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Clinics

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Community Join

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community 9 month update (0.5 dut/2.5 oral min)

in Progress Pictures 64 upvotes 5 months ago

The user reported improved hair quality and faster growth after switching from finasteride and topical minoxidil to dutasteride and oral minoxidil, despite experiencing significant shedding. They take separate pills daily and are optimistic about future progress.

community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1391 upvotes 1 year ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

community Innovative hair loss treatment can restore 90% of lost hair

890 upvotes 1 year ago

A new hair loss treatment using dermal exosomes can restore up to 90% of lost hair in mice. Users discuss potential human trials and compare it to Minoxidil and Finasteride.

community Finally. Some tangible results. 9mos difference.

188 upvotes 9 months ago

The user experienced significant hair improvement over nine months using a routine of oral finasteride, mixed topical and oral minoxidil, microneedling, and Head & Shoulders shampoo. The user attributes the progress to oral minoxidil and reduced stress during paternity leave.

community Oral Fin+Min: Digital microscope scalp review - Day 0 Vs 3 Months

1399 upvotes 1 year ago

A user used oral finasteride and minoxidil for hair loss, seeing new hair growth under a microscope but no visible change. Commenters debated if the growth was real hair or fibers, and the user will update every 90 days.

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Experts

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63
Dermatologist
Shailaja Pm, MBBS
Bengaluru, Karnataka, India

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Shailaja Pm, MBBS