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Glossary Platelet-Derived Growth Factor AA

stimulates cell growth and tissue repair, including hair follicles

Platelet-Derived Growth Factor AA (PDGF-AA) is a protein that plays a crucial role in cell growth, healing, and development. It is one of the isoforms of PDGF, which are important for stimulating the proliferation and differentiation of cells, particularly in the context of wound healing and tissue repair. In the realm of hair biology, PDGF-AA can influence hair follicle development and regeneration, making it a potential target for treatments related to hair loss and alopecia.

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Research

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research Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal

37 citations , April 2017 in “npj Regenerative Medicine”

This study found that platelet-derived growth factor signaling is crucial for maintaining the hair follicle dermal stem cell pool and supporting their regenerative capacity.

research The effect of platelet-derived growth factor-aa (PDGFA) conjugated with low-molecular-weight protamine (LMWP) on hair loss improvement effect

December 2024 in “Biochemical and Biophysical Research Communications”

LMWP-PDGFA shows promise for improving hair health and treating hair loss with fewer side effects.

research Expression of CD117 and platelet-derived growth factor receptor α in patients with alopecia areata

1 citations , January 2020 in “Indian journal of dermatology, venereology, and leprology”

This study found that the expression of CD117 and platelet-derived growth factor receptor α differs in alopecia areata tissue compared to normal controls, with platelet-derived growth factor receptor α correlating with disease severity.

research A New Advance in Baldness Surgery Using Platelet-Derived Growth Factor

17 citations , May 2005 in “Hair transplant forum international”

This study evaluated the effectiveness of follicular units and growth factors derived from autologous platelet-rich plasma in improving hair growth and density in 23 male patients with pattern hair loss.

research Effect of 10% calcium gluconate on the activation of platelet-rich plasma obtained at different centrifugation conditions on the expression of platelet derived growth factor-BB (PDGF-BB)

January 2024 in “Universidad Peruana Cayetano Heredia Institutional Repository”

In this in vitro study, simple centrifugation with calcium gluconate activation led to a significantly higher release of PDGF-BB in PRP compared to other methods, which may inform improved clinical PRP preparation protocols.

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Learn

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learn Platelet-Rich Plasma

growth factors taken from your blood and injected into your scalp to stimulate hair

What is Platelet-Derived Growth Factor Beta Polypeptide, and how does it help stimulate new hair growth? PDGF-BB is a growth factor that signals to dermal papilla cells and promotes blood-vessel formation; mouse studies report it can push follicles into the growth phase, and human evidence comes only indirectly from PRP trials. No PDGF product is approved for hair restoration and there is no published human trial of PDGF-BB on its own.

learn Epidermal Growth Factor

learn Beta Polypeptide

learn Thymosin Beta 4

learn Vascular Endothelial Growth Factor

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Community Join

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community Growth factors, VEGF, And more,possible permanent cure for people with moderate hairloss?

3 upvotes 1 year ago

The user discusses using dutasteride to stop hair loss and bimatoprost for regrowth. They plan to use VEGF with hydrogels for potentially permanent hair follicle improvement and suggest PRP as an alternative.

community A Theory on Why Microneedling Works

175 upvotes 6 years ago

Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.

community My derm said they came up with a new serum that is better then fin? What’s y’all’s thoughts

7 months ago

A new serum claims to enhance hair regrowth by amplifying oxygen delivery, improving the effectiveness of treatments like exosomes and peptides. Users are skeptical, questioning its efficacy compared to established treatments like Minoxidil and Finasteride.

community Comprehensive Microneedling Guide

292 upvotes 4 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community 1 month on minoxidil - progress pictures

in Is this regrowth? 91 upvotes 1 year ago

The user has been using finasteride for years and recently started using minoxidil foam, noticing some increased hair density and vellus hairs after one month. They report no scalp issues or side effects and also use a ketoconazole shampoo weekly.

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