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A Novel Finasteride 0.25% Topical Solution for Androgenetic Alopecia: Pharmacokinetics and Effects on Plasma Androgen Levels in Healthy Male Volunteers

research A novel finasteride 0.25% topical solution for androgenetic alopecia: pharmacokinetics and effects on plasma androgen levels in healthy male volunteers

50 citations , July 2014 in “International Journal of Clinical Pharmacology and Therapeutics”

This study found that both topical and oral finasteride significantly reduced plasma DHT after one week, with lower finasteride plasma exposure for the topical formulation.

Plasma C19 Steroid Sulfate Levels and Indices of Androgen Bioavailability in Female Pattern Androgenic Alopecia

research PLASMA C19 STEROID SULPHATE LEVELS AND INDICES OF ANDROGEN BIOAVAILABILITY IN FEMALE PATTERN ANDROGENIC ALOPECIA

32 citations , January 1990 in “Clinical Endocrinology”

This study found that women with female pattern androgenic alopecia have significantly higher levels of certain androgens and androgen sulfates compared to normal premenopausal women, suggesting markers for diagnosis and treatment efficacy.

research Determinants of Plasma Androgen and Estrogen Levels in Men

September 2006 in “Data Archiving and Networked Services (DANS)”

This article discusses the testosterone and estradiol levels in men, examining their roles and suggesting the need for better understanding to differentiate between normal and abnormal levels related to androgen deficiency symptoms, without reporting new clinical results.

Daily Intake of Alfalfa Sprouts, But Not Broccoli Sprouts, Influences Plasma Levels of Androgen in Middle-Aged Males

research Daily intake of alfalfa sprouts, but not broccoli sprouts, influence plasma levels of androgen in middle-aged males

January 2018 in “Journal of translational science”

In this study, oral broccoli sprouts intake did not affect plasma androgen levels in males, while alfalfa sprouts intake increased testosterone and DHT levels, which may help prevent male late onset hypogonadism.

research Puberty in Boys: Correlation of Plasma Levels of Gonadotropins (LH, FSH), Androgens (Testosterone, Androstenedione, Dehydroepiandrosterone and Its Sulfate), Estrogens (Estrone and Estradiol) and Progestins (Progesterone and 17-Hydroxyprogesterone)

96 citations , September 1975 in “The Journal of Clinical Endocrinology & Metabolism”

In this study, significant elevations of DHA and testosterone were associated with pubic hair development and voice changes in boys during puberty.

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Community Join

5 / 162 results

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 140 upvotes 2 years ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Has any data on systemic absorption of pyrilutamide been published?

1 upvotes 4 months ago

Pyrilutamide shows minimal systemic absorption with low plasma levels and no accumulation, suggesting it's unlikely to cause systemic side effects. However, full results are not yet published in scientific journals.

community question about dutasteride and oral minoxidil

in Treatment 1 month ago

A 22-year-old has been using dutasteride, oral minoxidil, platelet-rich plasma therapy, and low-level laser therapy for hair loss but is still experiencing progression from Norwood 2 to 3. Others suggest increasing dutasteride dosage or trying additional treatments like RU58841 or topical finasteride.

community My DHT levels have increased after taking 0.25mg Fin for 47 days!

186 upvotes 1 year ago

A user experienced increased hair shedding and unchanged DHT levels after taking 0.25mg of finasteride for 47 days, leading them to increase the dose to 0.5mg. Others discussed varying experiences with finasteride, minoxidil, and the importance of measuring scalp DHT.

community Any treatment not nuking systemic DHT levels?

16 upvotes 7 months ago

Hair loss treatments that avoid significantly lowering systemic DHT levels, focusing on topical options like dutasteride mesotherapy, minoxidil, and ketoconazole. The user is exploring alternatives like KX-826 and RU58841 due to concerns about hormone levels.

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