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Topical Application of Aprepitant Inhibits Erlotinib-Induced Facial Dermatitis and Hair Loss

research Topical Application of Aprepitant Inhibits Erlotinib-induced Facial Dermatitis/Hair Loss

January 2024 in “Journal of dermatology and skin science”

In this study, researchers found that applying topical aprepitant, which blocks substance P receptors, significantly reduced facial dermatitis and hair loss in rats experiencing erlotinib-induced skin side effects, highlighting the neurogenic inflammation's role and the protective effect of ROS inhibition.

research Can gut flora changes be new biomarkers for depression?

1 citations , September 2017 in “Frontiers in Laboratory Medicine”

This review discusses recent research on the relationship between gut microflora and depression, highlighting the potential for new insights into the pathogenesis and treatment of major depressive disorder.

research Comparison of the impact of intermittent fasting diet alone or in conjunction with probiotic supplementation versus calorie-restricted diet on inflammatory, oxidative stress, and antioxidant capacity biomarkers in women with polycystic ovary syndrome: A randomized placebo-controlled trial

3 citations , January 2025 in “Journal of Research in Medical Sciences”

This study reported that among obese women with PCOS, neither early time-restricted eating (eTRE) alone nor combined with probiotics showed significant improvements in blood pressure, inflammatory markers, oxidative stress, or antioxidant capacity compared to a standard reduced-calorie diet.

research Gender Differences in the Regulation of Blood Pressure

1231 citations , May 2001 in “Hypertension”

This review discusses the potential mechanisms by which androgens may elevate blood pressure, particularly through impacts on the renin-angiotensin system, but reports no new experimental results.

research Lignans and Neolignans: Plant secondary metabolites as a reservoir of biologically active substances

112 citations , May 2019 in “Pharmacological Research”

This review discusses the isolation, structure, and bioactivity of lignans and neolignans from 2016 to mid-2018, reporting no new clinical results but highlighting their potential protective properties against diseases such as cancer and neurodegeneration.

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Community Join

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community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 140 upvotes 2 years ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community NW4 -> NW 2.5 (2.5 months progress) RU 8.5-9% ED and topical Dut .1% + RU 5% once a week.

108 upvotes 3 years ago

User shows hair loss progress from NW4 to NW2.5 in 2.5 months using RU 8.5-9% daily and topical Dut .1% + RU 5% weekly. Discussion includes managing tension in African American hair and representation of different hair types.

community Hy-tissue PRP 50 Experience ??

in Product 4 upvotes 1 year ago

PRP treatments have been effective for the user, with a new recommendation of using a high-quality plasma kit once a year. The user seeks experiences with this specific PRP approach.

community What about botox injections on the scalp?

6 upvotes 3 years ago

Botox injections on the scalp may help with hair loss, as one small study showed improvement in 8 out of 10 subjects. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

14 upvotes 6 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

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