research PKC downregulation upon rapamycin treatment attenuates mitochondrial disease
Martin-Perez et al. show that rapamycin's beneficial effects in a mouse model of Leigh syndrome are linked to the downregulation of protein kinase C.
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research Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin
This study found that in a mouse model of Leigh syndrome, rapamycin alters brain proteome and may extend survival by targeting protein kinase C.
research Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation
This study found that inhibiting PKC-β activity with bisindolylmaleimide reduces pigmentation in the skin and hair of guinea pigs and mice by preventing tyrosinase activation.
research Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study
This study found that procyanidin B-2 may promote hair growth by reducing expression and inhibiting translocation of PKC isozymes in murine hair epithelial cells.
research Lipid signaling in keratinocytes: Lipin-1 plays a PArt
This study suggests that lipin-1 plays a crucial role in keratinocyte differentiation by modulating protein kinase C activity through diacylglycerol levels, with implications for skin biology.
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