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Hirsutism and the Variable Response of the Pilosebaceous Unit to Androgens

research Hirsutism and the Variable Response of the Pilosebaceous Unit to Androgen

56 citations , August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

This review discusses the complex interaction between androgens and hair follicle biology, highlighting the need for a better understanding to improve hirsutism treatments, but reports no new results.

research Strategic Targets in Acne: The Comedone Switch in Question

47 citations , January 2015 in “Dermatology”

This review revisits mechanisms underlying acne lesion formation and suggests that preventing comedone development requires controlling critical factors in the pilosebaceous follicle before acne involvement.

research Frontiers in the (Neuro-)endocrine Controls of Hair Growth

22 citations , November 2007 in “Journal of Investigative Dermatology Symposium Proceedings”

This presentation reviews recent discoveries about signaling mechanisms in hair follicles and their potential influence on hair cycle control and melanogenesis, without presenting new experimental results.

research Transcriptome Profiling of Pilosebaceous Units in Male Androgenetic Alopecia Reveals Altered Junctional Networks

February 2021 in “Journal of Investigative Dermatology”

This study found that specific junctional proteins are significantly downregulated in balding regions of the scalp in men with androgenetic alopecia, suggesting disrupted cell communication may play a role in hair loss.

research Function-driven geometry directs human pilosebaceous unit development

September 2026 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study mapped the development of the human pilosebaceous unit in prenatal scalp skin using multi-modal analysis, finding that epithelial-mesenchymal interactions guide cellular fate and validated tissue-patterning through a hair-bearing skin organoid model.

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community Supposedly dairy contains precursors to DHT that are already 5a-reduced and convert to DHT independent of 5a-reductase inhibition

26 upvotes 5 months ago

Dairy may contain DHT precursors that could affect hair loss and prostate health, with some users noting reduced hair shedding after eliminating dairy. Individual responses to dairy and DHT blockers vary, with some attributing hair health to diet changes and others seeing no impact.

community Phase II topical dut study - outperforms oral fin with a minor DHT reduction

in Research/Science 61 upvotes 7 months ago

Topical dutasteride 0.05% is more effective for hair growth than oral finasteride 1mg, with minimal DHT reduction. The formulation uses castor oil and MCTs for better absorption but is not widely available until 2028.

community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

59 upvotes 5 months ago

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

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Hair Systems
Hair Response Inc.Arlington Heights, IL · US

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