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research Characteristics of the structural components of pilosebaceous follicles in the differential diagnosis of non-cicatricial alopecia

December 2025 in “Russian Journal of Skin and Venereal Diseases”

This study found that in patients with non-cicatricial alopecia, hair follicles and their sheaths were thinner compared to controls, especially in cases of alopecia areata and telogen effluvium, with notable thinning beginning in the subcutaneous fat tissue.

research [Hyperandrogenism and pilosebaceous follicles].

November 1993 in “PubMed”

This article reviews the role of androgens in skin metabolism and diseases like acne and androgenic alopecia, but reports no new clinical results; the authors note unresolved issues regarding androgen interactions in skin structures.

research Culture of the human pilosebaceous unit, hair follicle and sebaceous gland

30 citations , April 2018 in “Experimental Dermatology”

This review discusses the historical development and current challenges in in vitro hair follicle culture, highlighting a need for advanced models using cell lines and tissue engineering, and reports no new results.

research Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne

43 citations , November 2018 in “Nature Communications”

This genome-wide association study identified 20 genetic signals at 15 risk loci related to severe acne, revealing new insights into its genetic predisposition, particularly affecting skin structure and maintenance.

research Androgen physiology and the cutaneous pilosebaceous unit.

21 citations , May 2001 in “PubMed”

This paper reviews the significance of androgen hormones in hair and skin conditions like alopecia, hirsutism, and acne, and reports no new clinical findings.

View more "pilosebaceous follicle" in research →

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community Why liposomal finasteride and minoxidil may be better than traditional topical solutions.

in Research/Science 2 upvotes 1 year ago

Liposomal formulations of finasteride and minoxidil may enhance drug delivery to the skin and hair follicles more effectively than traditional solutions, potentially improving treatment outcomes. However, more human clinical trials are needed to confirm these benefits.

community Supposedly dairy contains precursors to DHT that are already 5a-reduced and convert to DHT independent of 5a-reductase inhibition

26 upvotes 5 months ago

Dairy may contain DHT precursors that could affect hair loss and prostate health, with some users noting reduced hair shedding after eliminating dairy. Individual responses to dairy and DHT blockers vary, with some attributing hair health to diet changes and others seeing no impact.

community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

5 upvotes 8 months ago

Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

59 upvotes 6 months ago

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

community Phase II topical dut study - outperforms oral fin with a minor DHT reduction

in Research/Science 61 upvotes 7 months ago

Topical dutasteride 0.05% is more effective for hair growth than oral finasteride 1mg, with minimal DHT reduction. The formulation uses castor oil and MCTs for better absorption but is not widely available until 2028.

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