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GlossaryPhototoxicity

skin reaction from sunlight exposure to certain chemicals

Phototoxicity refers to a skin reaction that occurs when certain chemicals or medications on the skin are exposed to sunlight, leading to damage. This can result in redness, inflammation, and sometimes blistering, similar to a severe sunburn. For professionals, it's important to note that phototoxic reactions are typically caused by the interaction of ultraviolet (UV) light with photosensitizing agents, which can be found in some topical treatments, systemic medications, or even certain plant compounds.

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research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

23 citations, October 2008 in “Journal of medicinal chemistry”

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

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community Scalp Sunburns cause permanent hair loss. UPF hats protect you. Watch if you use Tretinoin on the scalp

in Technology 4 months ago

Sunburns on the scalp can cause permanent hair loss, especially for those using Tretinoin or Tacrolimus. Wearing UPF 50+ hats is recommended to protect against UV radiation.

community Minoxidil can prevent hair follicle miniaturization!?

in Minoxidil 6 upvotes 3 years ago

Minoxidil can prevent hair follicle miniaturization, not just stimulate hair growth. Finasteride and dutasteride don't work for everyone, suggesting DHT may not be the sole cause of hair loss; hair loss could be due to multiple factors, including autoimmune conditions.

community Effect of dutasteride 0.5 mg/d in men who don't respond to finasteride (study)

in Research/Science 31 upvotes 2 weeks ago

Dutasteride improved hair density and thickness in men who didn't respond to finasteride, with some experiencing transient sexual dysfunction. Users discussed switching from finasteride to dutasteride, noting initial shedding but eventual hair improvement.

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