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GlossaryPhototoxicity

skin reaction from sunlight exposure to certain chemicals

Phototoxicity refers to a skin reaction that occurs when certain chemicals or medications on the skin are exposed to sunlight, leading to damage. This can result in redness, inflammation, and sometimes blistering, similar to a severe sunburn. For professionals, it's important to note that phototoxic reactions are typically caused by the interaction of ultraviolet (UV) light with photosensitizing agents, which can be found in some topical treatments, systemic medications, or even certain plant compounds.

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research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

23 citations, October 2008 in “Journal of medicinal chemistry”

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

Successful Treatment of Resistant Alopecia Areata with a Phototoxic Dose of Ultraviolet A After Topical 8-Methoxypsoralen Application

research Successful Treatment of Resistant Alopecia Areata with a Phototoxic Dose of Ultraviolet A After Topical 8-Methoxypsoralen Application

12 citations, January 2011 in “Photodermatology, photoimmunology & photomedicine”

This therapy effectively treats resistant alopecia areata with minimal side effects.

research Effects of Visible Light on the Skin

195 citations, January 2008 in “Photochemistry and Photobiology”

Visible light can damage skin and most sunscreens don't block it well; more research is needed on its effects and protection methods.

research Adverse Effects of Voriconazole: Over a Decade of Use

100 citations, September 2016 in “Clinical transplantation/Clinical transplantation.”

Voriconazole can cause serious side effects, especially in long-term use.

research Adverse Effects Associated with Long-Term Administration of Azole Antifungal Agents

90 citations, May 2019 in “Drugs”

Long-term use of azole antifungals can cause hair loss, hormonal imbalances, and severe skin reactions.

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community Scalp Sunburns cause permanent hair loss. UPF hats protect you. Watch if you use Tretinoin on the scalp

in Technology 2 months ago

Sunburns on the scalp can cause permanent hair loss, especially for those using Tretinoin or Tacrolimus. Wearing UPF 50+ hats is recommended to protect against UV radiation.

community Minoxidil can prevent hair follicle miniaturization!?

in Minoxidil 6 upvotes 3 years ago

Minoxidil can prevent hair follicle miniaturization, not just stimulate hair growth. Finasteride and dutasteride don't work for everyone, suggesting DHT may not be the sole cause of hair loss; hair loss could be due to multiple factors, including autoimmune conditions.

community Actifollic Will sell pyrilutamide😱

in Treatment 18 upvotes 2 years ago

Actifollic selling Pyrilutamide as a treatment for hair loss, with people debating its efficacy compared to Minoxidil and Finasteride in combination with RU58841.

community Since there is so much hype for cosmeRNA and HMI-115...

in Chat 48 upvotes 1 year ago

Exploring different treatments for hair loss, such as cosmeRNA and HMI-115 which are small interference messenger RNA that inhibits the DHT receptor and an antibody that binds to the prolactin (PRL) receptor respectively; and researching mechanism and environment of hyperresponders.

community What else is good. Besides the big 3.

in Chat 36 upvotes 1 month ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

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