Characterization of Photosensitizing Effects by Topical Delivery of Alpha-Terthienyl and UVA

January 1985 in “ Clinical research ”

Wm Rampone, Jl Mccullough, Gd Weinstein, Chn Towers, Michael W. Berns

TLDR Topical alpha-terthienyl with UVA may safely treat psoriasis without cancer risk.

The study investigated the phototoxic effects of alpha-terthienyl (a-T), a compound derived from marigolds, when applied topically and exposed to UVA radiation. Conducted on guinea pig skin, the research demonstrated that a-T in a 3% Azone gel penetrated the skin in a dose-dependent manner, with maximum sensitization occurring 1 hour after application. The phototoxic response included erythema, edema, crusting, erosion, and inhibition of hair growth, observed 72 hours to 7 days post-irradiation. The study suggested that topical a-T combined with UVA could be a safer alternative for photochemotherapy in treating psoriasis and other skin diseases, as it does not interact with DNA and avoids the carcinogenic risks associated with other treatments like psoralens.

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research Characterization of Cutaneous Phototoxicity Induced by Topical Alpha-Terthienyl and Ultraviolet A Radiation

22 citations , September 1986 in “Journal of Investigative Dermatology”

Low-dose topical alpha-terthienyl may be a safer option for treating skin conditions with light therapy.